Chromologic LLC

Peter Bui

Naresh Menon

Cheryl Tan

An apparatus is disclosed for separating and preserving biomolecules of a biological fluid sample. The apparatus includes an assembly having sides forming a hollow shape having a first opening at one end and second opening at the opposite end, a sample mixing chamber positioned adjacent the first opening within the assembly, the sample mixing chamber from which a flow of the biological fluid sample is actuated in a direction from the sample mixing chamber to the first matrix layer, the sample mixing chamber being in a direction downstream of the first opening, a first valve positioned between the sample mixing chamber and the first matrix layer, the first valve configured to control the flow to the first matrix layer, a first input in fluid communication with the sample mixing chamber and positioned upstream of the first valve, a second input positioned between the first matrix layer and the second matrix layer, and a second valve positioned between the second matrix layer and the second opening, the second valve configured to control the flow to the second matrix layer.

Integrated membrane device

The apparatus of the present invention comprises an integrated membrane for separation and preservation of biomolecules. Biomolecules, such as those in blood, can be separated and preserved. The apparatus includes a housing having a matrix portion, and a fluid collection portion disposed within an inner cavity. The housing further includes an aperture permitting access to the inner cavity. The apparatus also includes a matrix disposed within the matrix portion. The matrix includes a first layer for collecting cells from the fluid, a second layer for protein adsorption, and a third layer for nucleic acid adsorption. Fluid enters the housing through the aperture, passes through the matrix, and into the fluid collection portion. Cells from the fluid in a layer of the matrix are collected; adsorbing protein from the fluid in a layer of the matrix; and adsorbing nucleic acid from the fluid in a layer of the matrix.

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Monrovia, CA, United States of America

Peter Bui