University of Miami

Nogra Pharma Limited

Converge Biotech Inc.

Peter Buchwald

Camillo D Ricordi

Luca Inverardi

Antonello Pileggi

Giovanni Monteleone

Alice Tomei

Jeffrey Alan Hubbell

Nicholas S Bodor

Christopher A Fraker

Norma Sue Kenyon

Fabio Grassi

Paul Latta

Cheryl Stabler Anderson

Disclosed herein are inhibitors of TNF superfamily costimulatory interactions, and methods for their use in modulating TNF superfamily costimulatory interactions and treating immune system related disorders. In particular, disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof: wherein the substituents are described herein.

Inhibitors of TNF superfamily costimulatory interactions and methods for uses of the same

Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.

Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation

A device () for receiving implanted biological material includes a mechanoprotective surface () defining an adjacent space, an assembly () for locally delivering media to said space, and a pump or slow/sustained release reservoir structure () operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.

Therapeutic hybrid implantable devices

Growing community of inventors

Miami, FL, United States of America

Peter Buchwald