Health Research, Inc.

Washington University

Musc Foundation for Research Development

Peter Brunner

Gerwin Schalk

Jonathan Rickel Wolpaw

Dennis J McFarland

Aiko K Thompson

Xiang Yang Chen

Eric Leuthardt

Adriana De Pesters

William G Coon

Kara Donovan

Aiko Thompson

Eric C Leuthardt

The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient's vagus nerve within a patient's ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.

Systems and methods for detecting motoneuron excitability

The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor. Also provided is a system for providing neurofeedback including electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and an output device configured to communicate changes in, increases in, decreases in, or maintenance of instantaneous voltage amplitudes, or any combination, to a participant in a neurofeedback session.

Measurement of cortical excitability

The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

System and related method to restore and/or improve nervous system functions by modifying specific nervous system pathways

Method and device to restore and/or improve nervous system functions by modifying specific nervous system pathways

A method and system are provided for analyzing electromagnetic brain signals such as EEG and ECoG signals in a subject in real time and which avoids the need for time-intensive retrospective analysis of brain activity in the subject. This can be applied to all complex systems with multiple fluctuating signals to identify and predict significant events.

Method for analyzing function of the brain and other complex systems

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Albany, NY, United States of America

Peter Brunner