Seno Medical Instruments, Inc.

Peter Brecht

Jason Zalev

Bryan Clingman

Donald G Herzog

Alexander A Oraevsky

Sergey A Ermilov

Andre Conjusteau

Richard Su

Vyacheslav Nadvoretskiy

Alexander Oraevsky

Sergey Ermilov

A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.

Dual modality imaging system for coregistered functional and anatomical mapping

An optoacoustic imaging system includes a hand-held imaging probe having a light emitting portion and an array of ultrasonic transducers. The probe includes an acoustic lens having an optically reflective material that operates to avoid image artifacts associated with light interactions with the acoustic lens. The optically reflective material may be a thin, highly optically reflective metallic layer. The acoustic lens may be formed from a material such as silicone rubber filled with titanium dioxide or barium sulfate that allows it to reflect and scatter light from illumination components with substantially no absorption of such light, and yet be optically opaque. The probe may include a housing that provides hypo-echoic encapsulation of the probe. An assembly of the array of ultrasonic transducers may include a hypo-echoic material. The probe may include optical windows, each comprising one or more anti-reflection coated plates with acoustic impedance matching that of tissues to be imaged.

Optoacoustic imaging system having handheld probe utilizing optically reflective material

A real-time imaging method that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.

Method for dual modality optoacoustic imaging

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Santa Monica, CA, United States of America

Peter Brecht