Schering Aktiengesellschaft

Shering Ag

Peter Blaszkiewicz

Ulrich Speck

Orlin Petrov

Johannes Platzek

Heinz Gries

Hanns-Joachim Weinmann

Ulrich Niedballa

Dieter Seidelmann

Hans Bauer

Erich Klieger

Holger Hoffmann

The invention relates to crystalline lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane, their production and the recovery of the salt-free gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane from the latter without the use of ion exchangers.

Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, their production and use

The invention relates to the process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cyclene, the corresponding mono- and 1,7-bis-N-.beta.-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li-salt complexes as intermediate products in the process and the use of the N-(6-hydroxy-2,3-dimethyl-1,3-dioxepan-5-yl)-1,4,7,10-tetraazacyclododecan e-LiCl complex for the production of gadobutrol [Gd ocmplex of N-(1-hydroxy-methyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecane].

Process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cyclene;

5-Hydroxyacetamido-2,4,6-triido-isophthalic acid-(2,3-dihydroxy-N-methyl-propyl)-(2-hydroxy-ethyl)-diamide is outstandingly suitable as x-ray contrast medium.

Nonionic x-ray contrast medium with high iodine content

Fluorosubstituted benzene derivatives of Formula I ##STR1## wherein Y, R.sup.2, R.sup.3 and R.sup.4 are defined herein, are NMR diagnostic agents.

Method of using fluorosubstituted benzene derivatives in F-NMR imaging

Dicarboxylic acid bis-(3,5-dicarbomoyl-2,4,6-triiodoanilides) of general formula I ##STR1## wherein the amide radicals --CONR.sup.1 R.sup.2 and --CONR.sup.3 R.sup.4 are different from one another and

Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) and x-ray

The invention relates to new substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilines), of general formula I ##STR1## in which R.sup.1 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2, wherein R.sup.1 and R.sup.2 are the same or different,

Substituted dicarboxylic

New triiodinated isophthalic acid diamides of the formula ##STR1## wherein the amide residues --CO--N.R.sub.1 R.sub.2 and --CO--N.R.sub.3 R.sub.4 are different from each other and

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Berlin, Germany

Peter Blaszkiewicz