Zeneca Limited

Peter Beverley Scholes

Francis Thomas Boyle

David Huw Davies

James Michael Wardleworth

Peter Wedderburn Kenny

Zbigniew Stanely Matusiak

Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R is for example H and further values as defined in the specification; R is for example H and further values as defined in the specification; R is for example H or a substituent having values as defined in the specification; p is 0-3 in which R values can be the same or different; L is a linking moiety for example &mdash;CO&mdash;NH &mdash; and further values as defined in the specification; A is selected from phenyl; naphthyl; a 5-10 membered monocyclic or bicyclic heteroaryl ring containing up to 5 heteroatoms where the heteroatoms are independently selected from O, N and S; or a &mdash;S&mdash;S-dimer thereof when R &equals;H; or an enantiomer, diastereoisomer, pharmaceutically acceptable salt, prodrug or solvate thereof together with a pharmaceutically acceptable diluent or carrier. A particular use is cancer therapy.

4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors

Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R,is for example H and further values as defined in the specification; R,is for example H and further values as defined in the specification; R,is for example H or a substituent having values as defined in the specification; p is 0-3 in which R,values can be the same or different; L is a linking moiety for example &mdash;CO&mdash;NH,&mdash; and further values as defined in the specification; A is selected from phenyl; naphthyl; a 5-10 membered monocyclic or bicyclic heteroaryl ring containing up to 5 heteroatoms where the heteroatoms are independently selected from O, N and S; or a &mdash;S&mdash;S&mdash; dimer thereof when R,&equals;H; or an enantiomer, diastereoisomer, pharmaceutically acceptable salt, prodrug or solvate thereof together with a pharmaceutically acceptable diluent or carrier. A particular use is cancer therapy.

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Macclesfield, United Kingdom

Peter Beverley Scholes