Roche Diagnostics Operations, Inc.

F. Hoffmann-la Roche Ag

Hoffmann-la Roche Inc.

Roche Diagnositcs Operations, Inc.

Roche Diagnostics Gmbh

Peter Berndt

Hanno Langen

Johann Karl

Werner Zolg

Marie-Luise Hagmann

Herbert Andres

Christof Fattinger

Remo Anton Hochstrasser

Gabriele Pestlin

Carlo S Effenhauser

Michael Tacke

Markus Roessler

Wolfgang Rollinger

Tom Kissling

Alois Rainer

Christoph Fattinger

Roger Steiner

Theresa Kott

Albert Roeder

Stefan Palme

Hans-Joachim Hoeltke

Stefan Evers

A system for dispensing a sample into a buffer liquid includes a pressure chamber having pressure supply means for generating an overpressure within the pressure chamber. An inlet capillary supplies a buffer liquid to an outlet end arranged in the pressure chamber, and an outlet capillary discharges the buffer liquid from the pressure chamber. The outlet capillary has an inlet end in the pressure chamber facing the outlet end of the inlet capillary to form a capillary gap. A dispenser having a dispensing end is in the pressure chamber at the capillary gap to allow the sample at the dispensing end to be dispensed into the buffer liquid entering the outlet capillary inlet end. The pressure chamber includes a sample port that allows the dispenser to be moved into and out of the pressure chamber.

System for dispensing a sample into a buffer liquid

A sorption micro-array () for sorbing a substance off an assay sample comprises a support () and a plurality of sorption elements (). The plurality of sorption elements () is arranged in a well defined geometry in connection with the support (), wherein the distance between each sorption element () and its adjacent sorption element () is predefined. Since all of the sorption elements () are arranged at a well defined location of the sorption micro-array (), e.g. in a row with well defined distances from each other, the output of an analysis of substances sorbed by each of the sorption elements () can exactly be allocated to a well defined location of an assay sample from which the substances have been sorbed. Like this, it is possible to provide an exact chemical output image of the micro-distribution of the substances of the assay sample. The sorption micro-array according to the invention allows a gentle fluidic pick up of substances essentially without impairing the substances wherein the location of the pick up on the assay sample is well defined.

Sorption micro-array

A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation elementfor the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in areaof a separation plane. According to the invention it is proposed that the separation elementhas a channel or transfer structurefor the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surfacethat is preferably suitable for mass spectroscopic analyses.

Separation method and device for protein mixtures

The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.

Cellular retinoic acid binding protein II as a marker for breast cancer

The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.

Use of protein ASC as a marker for breast cancer

Microtiter plate

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.

Nicotinamide N-methyltransferase as a marker for colorectal cancer

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Basel, Switzerland

Peter Berndt