Syngenta Participations Ag

Xencor, Inc.

Era Biotech, S.a.

Orpro Therapeutics, Inc.

Peter Bernard Heifetz

Edouard Guillaume Lebel

Scott Joseph Uknes

Eric Russell Ward

Stephen Arthur Goff

John R Desjarlais

Steven P Briggs

Umesh Muchhal

Peter Luginbuhl

Qiudeng Que

Jeng Shong Chen

Weining Gu

Eric Boudreau

Bipin Dalmia

Johannes Jacobus Ludgerus Gielen

Margarita Torrent Quetglas

Petrus Theodorus De Haan

David Andrew Patton

Joshua Zvi Levin

Pablo Marzábal Luna

Roser Pallisse Bergwerf

Miriam Bastida Virgili

Blanca Llompart Royo

Anic Deframond

Ma Immaculada Ilop Tous

Kevin James O'Connor

Ma Dolores Ludevid Múgica

Greg Del Val

Martha M Dunn

Joshua Levin

Kevin James O Connor

María Dolores Ludevid Mugica

Qiudeng c/o Syngenta Biotechnology Inc Que

David Andrew Syngenta Biotechnology Inc Patton

Mª Inmaculada Llop

M~ Inmaculada Llop

Pablo Marzabal Luna

Maria Dolores Ludevid Mugica

Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system.

Product and process for mucus viscosity normalization

The instant disclosure describes the application of genetic engineering techniques to produce cellulase in plants. Cellulase coding sequences operably linked to promoters active in plants may be transformed into the nuclear genome and/or the plastid genome of a plant. As cellulases may be toxic to plants, chemically-inducible or wound-inducible promoters may be employed. Additionally, the expressed cellulases may be targeted to vacuoles or other cellular organelles.

Transgenic plants expressing a cellulase

A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins.

Production of biologically active proteins

The present invention relates to the field of plastid transformation. The invention provides transformation vectors and methods to obtain transplastomic plants or algae having a transformed plastid comprising the steps of introducing into plastids a recombinant nucleic acid molecule or vector, and two phases of selection with first selection phase using a non-lethal compound and a second selection phase using a lethal compound. Alternatively, the dual selection method is conducted simultaneously using a lower concentration of the lethal compound.

Plant cell plastid transformation method using dual selection and producing transplastomic plants without antibiotic resistance genes

The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.

Nucleic acids and proteins with thioredoxin reductase activity

The invention provides novel stress tolerant transgenic plants which express trehalose 6-phosphate synthase and trehalose-6-phosphate phosphatase in their plastids.

Expression of trehalose 6-phosphate synthase and trehalose 6-phosphate phosphatase in plant plastids

The present invention relates to a method to confer resistance or tolerance to more than one virus from the group consisting of furovirus, potyvirus, tospovirus, and cucomovirus, using sense and antisense RNA fragments of a sequence from their genomes. The sense and antisense RNA fragments are capable of pairing and forming a double-stranded RNA molecule, thereby reducing expression of the viral genome.

Method for conferring resistance or tolerance aganist furovirus, potyvirus, tospovirus, and cucomovirus to plant cells

The invention provides novel transgenic plants which express trehalose biosynthetic genes, e.g., under control of an inducible promoter, which are developmentally normal, together with methods for improving stress tolerance in said plants, methods of improving food quality, and other methods of making and using the plants of the invention. The invention also provides nucleotide sequences encoded novel trehalose biosynthetic enzymes.

Expression of trehalose 6-phosphate synthase in plant plastids

A novel promoter isolated from the 5&prime; flanking region upstream of the coding sequence of the Arabidopsis plastid clpP gene is described. Also described are a novel method for utilizing protein-coding regions of plastid genes to isolate intervening regulatory sequences and a novel method for improving plastid transformation efficiency using exogenous plastid promoters that differ in nucleotide sequence from native plastid promoters.

ClpP plastid promoter sequence

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San Diego, CA, United States of America

Peter Bernard Heifetz