Harvard College

Roche Sequencing Solutions, Inc.

Peter B Stranges

George M Church

Aruna Ayer

Francois Pepin

Sukanya Srinivasa Rao Arun Punthambaker

The present disclosure is directed to compositions and methods for deriving a plurality of kinetics parameters () for at least two different enzyme variants in a multiplex manner using nanopore-based sequencing. In some embodiments, the systems and methods may be used to screen different nanopore variants, or different combinations of both nanopore variants and enzyme variants.

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Somerville, MA, United States of America

Peter B Stranges