The University of Queensland

Alchemia Limited

Peter Andrews

Mark Leslie Smythe

Michael Leo West

Wim F Meutermans

Tracie E Ramsdale

Ligong Liu

Giovanni Abbenante

Giang Thanh Le

Giovani Abbenante

Michael John Dooley

Chris Clark

Wim Meutermans

Tracie Elizabeth Ramsdale

New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide, .

Derivatives of monosaccharides for drug discovery

A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains of the constituent amino acid residues of a framework protein. A query is created which corresponds to a description of a location and orientation in 3D space of respective side chains of amino acid residues of a sample protein. The location and orientation in 3D space of constituent side-chains is preferably described as a C&#x3b1;&#x2013;C&#x3b2; vector. The query is used to search the database and thereby identify a hit which corresponds to a framework protein having structural similarity with said sample protein. Framework protein 'hits' so identified may be suitable candidates for further modification. A particular advantage of the present invention is that a modified framework protein may display one or more desired characteristics, such as a function similar to or inhibitory of the sample protein.

Protein engineering

Growing community of inventors

St. Lucia, Australia

Peter Andrews