Battelle Memorial Institute

Percuvision, LLC

Eli Lilly and Company

Ventaira Pharmaceuticals, Inc.

Peter Andrew Gaydos

Gregory A Trees

William Godwin Atterbury

Chad Edward Bouton

James E Dvorsky

Douglas E Boyd

Steven Michael Madland

David Arthur Holley

Mark Gerard Diller

David R Busick

Theodore Robert Adams

Brian Lipp

George C Proicou

Bobby Lee Walters

Daniel Duane Meek

Shannon Marie-Lynn Hoste

Bruce D Mcveety

Donna Marie Taylor

Douglas Edward Boyd

Daniel D Meek

A medication injector apparatus such as an injection pen. The injection pen may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose.

Medication injector apparatus with drive assembly that facilitates reset

The present invention is directed to metering devices, systems, and methods that mitigate differential thermal expansion/contraction for the efficient, accurate, and reproducible metered delivery of fluids. The present invention allows the net fluid volume and a plunger location within a fluid dispensing container to automatically adjust under the influence of differential thermal expansion/contraction between the fluid and the fluid dispensing container that the fluid is contained within. Further, the present invention allows the metering system drive to sense the adjusted plunger location and allows the metering system drive to re-zero itself to produce an accurate volumetric delivery of fluid from the fluid dispensing container. The metering system includes means for controlling the travel of the metering system drive, and hence the travel of the plunger into the fluid dispensing container, for delivering accurate/precise amounts of the fluid from the fluid dispensing container. The metering system may also mitigate dead volume in the metering system.

Accurate metering system

An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.

Nozzle for handheld pulmonary aerosol delivery device

Medical clamp

A multi-channel valve having a valve seat, a valve seal, and valve seal housing. The assembly of the apparatus creates a plurality of inlet, exit, and cross channels enclosed by elastomeric portions of a valve seal. The elastomeric portions of the valve seal create bounded distensible chambers. Pressure exerted by a fluid in excess of the cracking pressure of the seal tends to distend portions of the elastomeric seal and allow flow through and into the chambers. When inflow pressure falls, the elastic rebound of the elastomeric portions of the seal tends to expel fluid from the valve without backflow. Cross channel capacity allows mixing of the fluids. The plurality of, and differentials between, chambers allows one fluid to completely purge the valve of other fluids. The valve may be configured with additional backflow prevention capacities, such as channel variations, secondary elastomeric members, and variations in primary membrane properties.

Multi-channel valve

Growing community of inventors

Hilliard, OH, United States of America

Peter Andrew Gaydos