Wyeth Holdings Corporation

De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur

De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn,

De Staat Der Nederlanden, Vert. Door De Minister Van Vws

De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van

Peter Andre Van Der Ley

Peter Hoogerhout

Jan T Poolman

Peter R Paradiso

Robert C Seid, Jr

Emmanuel J H J Wiertz

John Edward Heckels

Ian Nicholas Clarke

Liana Juliana Josephine Margriet Steeghs

Hendrik Jan Hamstra

Johannes Gerardus Van De Winkel

Liana Juliana Steeghs

Johannes Petrus Tommassen

Jeroen Johannes Geurtsen

Outer-membrane vesicles, Class 1 outer membrane proteins offragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal disease.

Recombinant microorganism expressing meningococcal class 1 outer membrane protein

Outer-membrane vesicles, Class 1 outer membrane proteins of, fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal disease.

Meningococcal class 1 outer-membrane protein vaccine

The subject invention lies in the field of vaccines. Specifically new compounds that can be used as adjuvants are provided. Recombinant LPS having a reduced number of secondary acyl chains per molecule of LPS vis a vis the corresponding non modified LPS molecule, said secondary acyl chains being bound to primary acyl chains, said primary acyl chains being bound to the glucosamine of said recombinant LPS molecule, said recombinant LPS being homogenous in acylation pattern is an example of such a compound. Also recombinant LPS having a phosphate group attached to the glucosamine at the non reducing end of the LPS molecule and a phosphate group attached to the glucosamine at the reducing end of the molecule per recombinant LPS molecule provides a further example.

LPS with reduced toxicity from genetically modified gram negative bacteria

Immunogenic meningococcal LPS and other membrane vesicles and vaccine

Growing community of inventors

Utrecht, Netherlands

Peter Andre Van Der Ley