Merck Sharp + Dohme Corp.

Peter Alan Hunt

Angus Murray MacLeod

Jose Luis Castro Pineiro

Janusz Jozef Kulagowski

Kevin J Wilson

Tamara Ladduwahetty

Kevin John Merchant

Alexander Charles Humphries

Laura Catherine Cooper

Myra Gilligan

Philip Jones

Timothy Harrison

Matthew G Stanton

Eileen Mary Seward

Mark Stewart Chambers

Monique Bodil Van Niel

Neil Roy Curtis

Martin Richard Teall

Alan John Nadin

Clare London

Ian Churcher

Helen Jane Szekeres

Piotr Antoni Raubo

Sylvie Bourrain

Ian Thomas Huscroft

Michela Bettati

Elizabeth Mary Naylor

Angus Murray Macleod

Kevin Wilson

Compounds of formula I: are potent and selective antagonists of the human 5-HTreceptor, and hence useful in treatment of a variety of adverse conditions of the CNS.

Diarylsulfones as 5-HT2A antagonists

Substituted carbocyclic sulphonamide derivatives of formula (I), in which n is 0 or 1 and the other variables are as defined in the claims, are selective 5-HTreceptor antagonists and are thereby effective in the treatment of a variety of neurological conditions, including depression and sleep disorders. 

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The compounds of formula I: inhibit gamma secretase and hence are of utility in the treatment or prevention of Alzheimer's Disease.

Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease

The present invention relates to sulfone derivatives of formula (I):Ar&#x2014;SO&#x2014;CRR-L-N(R)Iwherein Ar, L, R, Rand Rare as defined herein, and pharmaceutically acceptable salts and N-oxides thereof, useful in the treatment of a condition which is susceptible to treatment by modulation of 5-HTreceptor activity, such as depression or a sleep disorder.

Sulfone derivatives as 5-HT7 receptor ligands

Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are di-astereoisomers of known protease inhibitors.

Gamma-secretase inhibitors

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Saffron Walden, United Kingdom

Peter Alan Hunt