Pfizer Corporation

Other

Peter A McCarthy

Frederick J Walker

Ernest S Hamanaka

Michael P Deninno

George Chang

Lawrence Alan Reiter

John L LaMattina

Michael Paul DeNinno

Thien Truong

Thien V Truong

Steroidal glycosides

Certain steroidal glycosides are useful as hypochoelsterolemic agents and antiatherosclerosis agents.

Sterodial glycosides for treating hypercholesterolemia

Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl

Steroidal glycosides for treating hypercholesterolemia

Compounds of the formula ##STR1## wherein R.sup.21 and R.sup.22 are as defined in the specification which are intermediates useful in the preparation of compounds of the formula ##STR2## and the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined in the specification. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

Intermediates for making N-aryl and N-heteroarylamide and urea

Variously substituted 3,5-dihydroxy-6,8-nonadienoic acids and esters, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiovascular diseases such as atherosclerosis.

3,5-dihydroxy-6,8-nonadienoic acids and derivatives as

N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as

A process for the synthesis of alpha,alpha-difluoroketones from alpha,alpha-difluoroacylsilanes and intermediates therefor.

Difluoroketones from difluoroacylsilanes

2-Guanidino-4-arylthiazole compounds of the formula ##STR1## a pharmaceutically acceptable cationic or acid addition salt thereof wherein

2-guanidino-4-arylthiazoles for treatment of peptic ulcers

Coin container

A reusable coin container serves as both a coin bank and a coin wrapper, and comprises two sections which snap together to form a pair of parallel cylinders each capable of holding a predetermined number of coins of a particular denomination. When the container is full, the sections are readily separated, and one section comprises a convenient holder from which coins may be dispensed. The container is arranged so that once full, insertion of an additional coin causes separation of the sections.

Growing community of inventors

Pawcatuck, CT, United States of America

Peter A McCarthy