Novaflux Inc.

Other

Massachusetts Institute of Technology

Breed Automotive Technology, Inc.

Therics, Inc.

Theken Spine, LLC

Princeton Trade & Technology, Inc.

Omnia Medical, LLC

3d Biotek, LLC

The United States of America As Represented by the United States

Afbs, Inc.

Michael J. Cima

Wendy E. Pryce Lewis

Charles William Rowe

Peter A. Materna

Peter A Materna

Mohamed Emam Labib

Stanislav S Dukhin

Ching-Yue Lai

Jeffrey Charles Robertson

Yacoob Tabani

Geoffrey Lawrence Mahon

Michael John Cima

James L Manganaro

Christopher M Gaylo

Wendy E Pryce Lewis

Thomas D Kelly

Qing Wen Liu

Thomas George West

Troy Schifano

Thomas J Bradbury

Timothy J Pryor

Daniel Johnson

Michael Dosch

Faribourz Payvandi

Wing K Lau

Zongsen Wang

Stephen Anderson

Ralph Leonard Hensler

Alfred Anthony Litwak

Seo Yean Sohn

Kathleen D Chesmel

Peng Yue

Azadeh Jadali

Richard Moakes

Leonid Lozinsky

John Soemer

Jaedeok Yoo

Brian Edward Hockett

James A Fairweather

Henry Leon Surprenant

James Bruffey

Eric A Lab

Donald C Monkhouse

Bret Everette Hartzell

Chen-Chao Wang

Abid Qureshi

Jeffrey A Fedor

Steven K Lee

Ralph L Hensler

Michael J Cima

Sunil Saini

Heather Ann Beam

Jennifer Patterson

Patrick Teung

Adolphe Youssef

Jeffrey A Russo

Dale G Davison

Provided among other things are a cleaning composition comprising a carrier fluid comprising in the carrier fluid polymer comprising particulate super absorbent polymer (PSAP), wherein the PSAP as in the cleaning composition is substantially at the percolation volume fraction or higher; wherein the cleaning composition can be passed over a surface driven by a pressure drop effective to render the composition traditional biofilm (TBF) cleaning effective and protein cleaning effective.

Cleaning composition with superabsorbent polymer

A bioreactor includes a reservoir container for holding a liquid medium, a duct providing a flowpath in a generally vertical direction upward from the reservoir container, a plurality of fiber assemblies located within the duct, a top of which is higher than a top of the plurality of fiber assemblies, and a circulation system. The upper end of the duct comprises an overflow wall surrounded by a moat, a bottom of which is lower than a top of the overflow wall. The upper end of the duct and moat contact a pocket region that is bounded by a structure that is connected to the duct and that is isolated from fluid communication with an exterior of the pocket region. The liquid medium flows over the overflow wall within the pocket region, contacts gas in the pocket region, overflows into the moat and is removed therefrom by the circulation system.

Bioreactor with scaffolds

An Underground Pumped Hydro Storage system may comprise a substrate, a large water-fillable bag, and an overburden causing pressure in the bag. The overburden may have nonuniformities of composition or dimension. Such nonuniformities may locally make overburden more flowable or gentle to the bag, at regions of relatively high shape change or flow during a cycle. Such nonuniformities may help prevent the overburden from freezing up in cold weather, or may enable a controlled progression of bag shapes. The overburden may have an irrigation hose buried in it. The bag edge joint may have any of various features that provide for a transition of local bending and load distribution near the joint between the bag upper and lower layers. An antechamber may be provided for access to the bag interior for robotic inspection or maintenance. The system may be deployed near a dam on a river.

Underground pumped hydro storage

Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.

Compositions for cleaning and decontamination

Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

Cartridges and systems for outside-in flow in membrane-based therapies

A bioreactor for culturing of cells is described. Screens suitable as a cell growth scaffold may comprise crossed fibers. Screens may be contained loosely in a screen holder, which in turn may be contained inside a manifold assembly. A lower manifold, screen holder and upper manifold may have identical or similar interior open cross-sections. Flow of liquid medium can occur upwardly through the array of screens, then flowing over a weir in the presence of an air pocket, and into a moat and a pump. The screen holder may have slots whose exterior-facing ligaments are rounded, and may have grooves whose interior-facing edges are rounded. These components may be located inside an incubator suitable to maintain desired environmental conditions and cleanliness.

An energy or water storage system can comprise a storage reservoir, a discharge reservoir, a pump for charging the storage reservoir, and a turbine or similar discharge device. The storage reservoir can comprise a flexible bag covered by overburden that creates pressure inside the bag. Energy is stored by raising the overburden. The bag can comprise a shaped internal filler piece to prevent formation of a crease at the bag edge. Solar panels can be mounted above any bag to make additional use of the land. Solar panels mounted on overburden can have tracking mechanisms and controls suitable to achieve desired orientation regardless of the slope of overburden. Elevation difference between the storage reservoir and discharge reservoir can be used, including an underground cavity. The bag can have internal tethers to influence bag shape.

Pressurized pumped hydro storage system

Provided among other things is a sampling system for determining an amount or type of contamination a narrow, elongated passageway in a medical device, said sampling system comprising: (a) a fluid supply system that supplies to said passageway a sampling liquid for flowing through said passageway and a gas for flowing through said passageway; and (b) a receiving container that receives liquid from said passageway, wherein said sampling liquid is sterile, wherein said sampling liquid is configured to allow recovery of viable pathogens from the passageway, and wherein said sampling liquid comprises an amount and selection of surfactant effective to enhance the dislodgement ofandbacteria from the narrow passageways.

Apparatus and methods for hygiene testing a medical device

Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.

Implants and constructs including hollow fibers

An implantable medical device, such as an intervertebral spacer, may comprise a polymeric component and a metallic component. The metallic component can contain both porous metal and substantially-solid metal. The polymeric material can contain particles of an osseointegrative material. The metallic component can be more protruding toward bone than the polymeric component while having a smaller dimension of roughness than the polymeric component. In embodiments, the pin may press-fit against substantially solid metal. The porous metal may surround solid metal which in turn may surround the pin. The pin may have a press-fit with metal and a looser fit with polymeric component, if the metal components and polymeric components are trapped. A pin may connect superior and inferior metal components by a press-fit. The central opening may be exposed to porous metal and also to substantially-solid metal and to polymer. Specific geometries of implants are disclosed.

Multi-material multi-component spinal implant

Growing community of inventors

Plainsboro, NJ, United States of America

Peter A Materna