US Government As Represented by the Secretary of the Army

Peter A Emanuel

Aleksandr E Miklos

Colin W Graham

Gregory A Thompson

Calvin W Chue

Jacob J Shaffer

Mark S Schlein

Peter J Schlitzkus

Kevin S Wallace

Ray Yin

James J Valdes

H Dupont Durst

Gary L Hagnauer

Calvin C Chue

Kyle D Ford

James P Burans

Mohyee E Eldefrawi

Daniel J Angelini

Kristy L Williams

A device and method for collecting, analyzing, and identifying chemical and biological samples in solid or liquid form is disclosed. The analysis compares the color change of Colorimetric Sensor Arrays (CSAs) over time with images for known materials/compounds contained in a library. The device can be used as a handheld or standalone device and integrates the sampling and detecting functions of the prior art into a single device that analyzes and identifies the sample without destroying it. The inventive volatile organic compound (VOC) technology device is also unique in that it relies on a comparison to a proprietary compound library that is supported by lab data. This compound library identifies the unique dye signature combinations that provide very accurate classification of a wide variety of chemical and biological agents.

Sampling and detection kit for chemical and biological materials

A sampling apparatus and method for collecting chemical and biological samples is disclosed and claimed. A surface sampling apparatus is designed to simplify taking successive environmental samples using one hand. In addition, the sampling bag used with the apparatus serves as both safety barrier and transport bag and is prepared with multiple sampling surfaces and in wet or dry formats.

One-handed surface sampling device

A self-contained, leak-proof sampling device and kit employing said device for collecting chemical and biological samples from various surfaces. The invention provides a sampling device and kit that may be employed to easily collect chemical and biological samples, safely transport the collected samples, safely dispense collected samples for analysis and provide optimum sample recovery. The sampling device is in the form of a leak proof container that comprises a lid and base. The lid contains a sterile absorbent collection means integrated into and positioned on the inside surface of the lid. The base contains a means to facilitate sample recovery from the absorbent collection means via compression and/or scraping of the absorbent collections means. Methods for employing the present invention are described herein.

Chemical and biological sampling device and kit and method of use thereof

Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of self-orienting on a surface to improve the orientation of the ligand/receptor binding domains within the bioassay at the nanoscopic level. In a preferred embodiment, the molecularly compact polymer comprises a dendrimer polymer such as a fifth generation polyamidoamine dendrimer having exterior surface hydroxyl and amine functional groups, and the ligand/receptor comprises an antibody or Fab.

Compositions and methods for enhancing bioassay performance

Recombinant antibody fragments (rFabs) specific to botulinum types A and B oxin complexes are provided. These rFabs are useful as immunosensors for detecting botulinum toxin in food, health care, and military applications. The DNA sequences coding for the rFabs are also disclosed.

Detection of botulinum toxin

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Abingdon, MD, United States of America

Peter A Emanuel