Mayo Foundation for Medical Education and Research

University of Washington

Peter A Cohen

Sandra J Gendler

Mary L Disis

Dustin B McCurry

Latha B Pathangey

Shannon E Smith

Joseph Lustgarten

Jessica E Gorman

Dominique B Hoelzinger

Ana L Dominguez

This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4T cells and/or antigen-specific CD8T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.

Methods and materials for expanding antigen-specific T cells in culture

This document provides methods and materials relating to isolated polypeptides, polypeptide preparations, vaccine preparations (e.g., anti-cancer vaccine preparations), and methods for vaccinating mammals. For example, polypeptides (e.g., CMV, MUC1, HER2, Mesothelin (MESO), TRAG-3, or CALR polypeptides) having the ability to be processed into different polypeptides such that the processed polypeptides as a group are capable of being presented by different MHC molecules present in a particular mammalian population are provided.

Methods and vaccines for inducing immune responses to multiple different MHC molecules

This document provides methods and materials related to using inhibitors of IL-9 signaling in conjunction with chemotherapy to treat cancer (e.g., solid tumors). For example, methods and materials for using inhibitors of IL-9 signaling (e.g., anti-IL9 antibody preparations) in conjunction with chemotherapy to treat cancer (e.g., solid tumors such as breast cancer tumors or colon cancer tumors) or to reduce the growth rate of cancer (e.g., solid tumors such as breast cancer tumors or colon cancer tumors) within a mammal are provided.

Blocking IL-9 signaling in conjunction with chemotherapy to treat cancer

Growing community of inventors

Scottsdale, AZ, United States of America

Peter A Cohen