Astra Pharmaceuticals Limited

Peter A Cage

Anthony Howard Ingall

Roger Victor Bonnert

Nicholas David Kindon

Francis Ince

Roger C Brown

David R Cheshire

Garry Pairaudeau

There are disclosed compounds of formula I, ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen or halogen, R.sup.3 and R.sup.4 independently represent phenyl, or alkyl C.sub.1-6 optionally substituted by one or more substituents selected from OR.sup.5, alkylthio C.sub.1-6, NR.sup.6 R.sup.7, phenyl, COOR.sup.8 and halogen,

N-alkyl-2-substituted ATP analogues for treatment of embolic disease

Biologically active benzothiazolone ethanamines

Benzothiazolone derivatives

There are disclosed compounds of formula I, ##STR1## wherein R.sup.1 and R.sup.2 independently represent hydrogen or halogen, R.sup.3 and R.sup.4 independently represent phenyl, or alkyl C.sub.1-6, optionally substituted by one or more substituents selected from OR.sup.5, alkylthio C.sub.1-6, NR.sup.6 R.sup.7, phenyl, COOR.sup.8 and halogen,

N-alkyl-2-substituted ATP analogues and administration to inhibit

There are disclosed compounds of formula I, ##STR1## wherein Q represents CR.sup.1 R.sup.2, R represents O or CR.sup.3 R.sup.4, W represents O or CH.sub.2, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen or halogen, X represents S(O).sub.n R.sup.5, alkyl C.sub.1-6 alkoxy C.sub.1-6, acylamino C.sub.1-6, CONR.sup.6 R.sup.7, NR.sup.8 R.sup.9, halogen, a 5- or 6-membered S containing heterocycle, or phenyl optionally substituted by alkyl C.sub.1-6, n represents 0, 1 or 2, R.sup.5 represents aryl or alkyl C.sub.1-6 optionally substituted by one or more substituents selected from hydroxy, alkoxy C.sub.1-6, halogen and aryl; R.sup.6, R.sup.7, R.sup.8 and R.sup.9 independently represent hydrogen or alkyl C.sub.1-6, Y represents NH.sub.2 or alkoxy C.sub.1-6, and Z represents an acidic moiety, in addition, when R represents CR.sup.3 R.sup.4, then --Q--Z may also represent hydroxy or --OP(O)(OH).sub.2, and pharmaceutically acceptable salts thereof, with certain provisos, for use as pharmaceuticals.

ADP and ATP analogues, process for making and administration to inhibit

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Shepshed, United Kingdom

Peter A Cage