The United States of America, As Represented by the Secretary, Department of Health and Human Services

Duke University

Perry J Blackshear

Darryl C Zeldin

Wi S Lai

Ester Carballo-Jane

Deborah J Stumpo

Joan P Graves

The invention provides glycated peptides and glycated fragments and glycated variants thereof, antibodies and aptamers which bind thereto, compositions and kits comprising the same, related conjugates, and a database comprising data indicating the concentration of glycated peptides present in diabetic and non-diabetic persons. The invention also provides a method of monitoring glycemic control, a method of treating or preventing diabetes, a method of preventing a complication of diabetes, a method of monitoring the status of diabetes, a method of determining the efficacy of a diabetes treatment, as well as methods of detecting diabetes or a predisposition thereto.

Glycated peptides and methods of use

The present disclosure relates to RFX4_v3 protein and nucleic acids encoding the RFX4_v3 protein. The present disclosure provides non-human transgenic animals with altered RFX4_v3 genes, and provides assays for the detection of RFX4_v3 and RFX4_v3 polymorphisms associated with disease states. The present disclosure additionally provides methods of determining a subjects' risk of developing congenital hydrocephalus, and treating or inhibiting its development.

Compositions and methods for diagnostics and therapeutics for hydrocephalus

The present invention provides methods of regulating the destruction of mRNA molecules containing an AU-rich element (ARE), for example, methods of stimulating the degradation of an mRNA molecule encoding TNF-&#x3b1;, and methods of inhibiting the degradation of an mRNA molecule encoding GM-CSF. Also provided are methods for identifying compounds that regulate the destruction of mRNA molecules containing AREs.

TTP-related zinc finger domains and methods of use

The present invention relates, in general, to tristetraprolin (TTP) and, in particular, to methods of modulating levels of tumor necrosis factor &agr; (TNF&agr;) using TTP or nucleic acid sequences encoding same. The invention further relates to methods of screening for compounds for their ability to inhibit TNF&agr; biosynthesis.

Method of screening a compound for its ability to enhance the ability of tristetraprolin to inhibit tumor necrosis factor

The present invention relates to a method of preventing caries and other sugar-dependent dental and oral lesions and to a carbohydrate binding protein-based composition suitable for use therein.

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Chapel Hill, NC, United States of America

Perry J Blackshear