Eli Lilly and Company

Perry C Heath

Ta-Sen Chou

Lawrence E Patterson

Leland O Weigel

John E Toth

Jane G Amos

Douglas E Prather

James E Audia

James Joseph Droste

Wayne Douglas Luke

Julie Kay Bush

Christopher William Doecke

Uko Effiong Udodong

John Brennan

The present invention provides crystalline biphenyl-4-carboxylic acid (R)-(6-(1-((4-fluorobenzyl)methylamino)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide hemihydrate, compositions thereof, methods of using the same, processes for making the same, and processes for making intermediates thereof.

Hemihydrate of a selective functional M1 muscarine receptor agonist

Synthesis of benzo[f]quinolinones

The compound 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate is described and claimed.

Imtermediate in process to make 2', 2'-difluoronucleosides

This invention provides for crystalline hydrochloride C.sub.1 -C.sub.3 alcohol solvate forms of the compound of formula (I): ##STR1## In particular, crystalline hydrochloride ethanol, methanol, and propanol solvates are disclosed.

Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof

A 1-pot process for preparing 10b-methyl-3-oxo-benzo[f] quinolines.

Syntheis of benzoquinolinones

This invention provides for crystalline hydrochloride C.sub.1 -C.sub.3 alcohol solvate forms of the compound of formula (I): ##STR1## In particular, crystalline hydrochloride ethanol, methanol, and propanol solvates are disclosed. Also disclosed are processess for preparing and using the above compounds.

The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 .alpha./.beta. mixture.

Process for preparing 2',2'-difluoronucleosides

Process for and intermediates of 2',2'-difluoronucleosides

7-Amino-3-pyridiniummethyl (and substituted pyridiniummethyl)-3-cephem-4-carboxylic acid hydrothiocyanate salts and a process for the preparation thereof are provided. The salts are useful for recovering the pyridinium nuclei from reaction mixtures in which they are formed or used.

Cephalosporin intermediate

(6R,7R)-7-[(Z)-2-(2-triphenylmethylaminothiazol-4-yl)-2-(2-tert.-butoxycarb onylprop-2-oxyimino)acetamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylat e is isolated by formation of N,N-dimethylacetamide solvates.

Process for preparing a cephalosporin compound

Stannic chloride is removed from organic solvent-based waste streams by precipitating the salt as a dimethyl sulfoxide complex.

Growing community of inventors

Indianapolis, IN, United States of America

Perry C Heath