Transgene S.a.

Institut National De La Sante Et De La Recherche Medicale

Perrine Martin

Nathalie Silvestre

Geneviève Inchauspe

Jean-Baptiste Marchand

Doris Schmitt

Alexei Evlachev

Genevieve Inchauspe

Anne Fournillier

Nourredine Himoudi

The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.

Composition for treating HBV infection

The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as well as a composition which can be used for eliciting an immune response to HBV with the goal of providing a protective or therapeutic effect against HBV infection.

Methods for treating or preventing HBV infection or HBV related diseases

HBV polymerase mutants

The invention relates to peptide compositions for use in the preparation of pharmaceutical compositions against hepatitis C virus, as well as corresponding methods.

Peptide compositions and their use in particular in the preparation of pharmaceutical compositions active against the hepatitis C virus

Growing community of inventors

L'Isle d'Abeau, France

Perrine Martin