Celgene Corporation

Pharmion Corporation

Celgene International Sarl

Periyandi Nagarajan

Chinnapillai Rajendiran

Hon-Wah Man

Terrence Joseph Connolly

Jasti Venkateswarlu

Jasti Venkateswarlau

Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

Methods of synthesis of (1R, 2R, 5R)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

Methods of synthesis of (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

Provided herein are processes for the preparation of 5-azacytidine, useful for treating, preventing, and/or managing diseases or conditions including cancer, disorders related to abnormal cell proliferation, hematologic disorders, and myelodysplastic syndromes (MDS), wherein 5-azacytidine is represented by the structure: 

Synthesis of 5-azacytidine

Growing community of inventors

Hyderabad Telangana, India

Periyandi Nagarajan