Pierre Fabre Medicament

Pere Tarin

Eulalia Ferret

Miguel Angel Asin

Rosa Arola

Amadeo Perez

Jesus Garcia

Eric Goutay

Montserrat Rutllan

Jésus Garcia

The invention concerns a method for preparing a pharmaceutical composition in the form of microspheres with prolonged release of a water-soluble active principle. The invention is characterized in that it comprises the following successive steps: dissolving an active principle in an appropriate amount of water; emulsifying the resulting aqueous solution of active principle with a d,l-lactide-co-glycolide matrix copolymer, of average molecular weight ranging between 40000 and 80000, dissolved in a chlorinated hydrocarbon, resulting in a first microfine and homogeneous emulsion; emulsifying said resulting first emulsion in an external aqueous phase, containing a surfactant, a viscosity-enhancing agent and an osmotic agent; extraction-evaporation of the solvent to obtain microspheres which are recuperated after filtering, washing and drying. The invention also concerns microspheres obtainable by implementing said method, having continuous release over a period of more than two months, advantageously over a period of at least three months.

Prolonged release biodegradable microspheres and method for preparing same

Biodegradable, controlled-release microspheres and process for preparing

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Sabadell, Spain

Pere Tarin