Dana-farber-cancer Institute Inc.

The Scripps Research Institute

The Broad Institute, Inc.

Pere Puigserver

Bruce M Spiegelman

Zhidan Wu

Guillaume Adelmant

Stuart L Schreiber

Theodore M Kamenecka

Patrick Griffin

Partha Pratim Nag

Joshua A Bittker

Roger Schilling

Kfir Sharabi

The present invention provides compounds, pharmaceutical compositions and methods for treating and/or preventing a metabolic condition, such as diabetes.

Selective inhibition of gluconeogenic activity

The invention provides isolated nucleic acid molecules, designated PGC-1and PGC-1nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

PGC-1 isoforms and uses therefor

The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

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Brookline, MA, United States of America

Pere Puigserver