J. Uriach & Cia, S.a.

Pere J Jimenez

Elena Carceller

Javier Bartroli

Carmen Almansa

Jordi Salas

Javier Forn

Marta Giral

Manel Merlos

Nuria Recasens

Julian Garcia-Rafanell

Rosa Ferrando

Dolors Balsa

Azo derivatives of 5-aminosalicylic acid

Piperidine derivatives with PAF antagonist activity

The present invention relates to new cyanomethylpyridine dervatives of formula I ##STR1## wherein Y represents N or CH; R.sub.1 represents hydrogen, fluoro, chloro, difluoro or dichloro; R.sub.2 represents hydrogen or C.sub.1-4 alkyl; n is 0 or 1; p is 0 or 1; A represents a covalent bond or a group of formula --CONHCH(Ar)--, --NHCH(Ar)--, --SO.sub.2 NHCH(Ar)--, --NHCONHCH(Ar)-- or --OCONHCH(Ar)--, and when p is 1, A can also represent --CH(Ar)NH--; and Ar represents phenyl or phenyl substituted with halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl. These compounds are PAF antagonist and/or 5-lipoxygenase inhibitors.

Cyanomethylpyridine derivatives

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Flix, Spain

Pere J Jimenez