Ge Healthcare Bio-sciences Ab

Ge Healthcare Bioprocess R&d Ab

Cytiva Sweden Ab

Cytiva Bioprocess R&d Ab

Per Uselius

Daniel Salomonsson

Manoj Kumar Ramakrishna

Sven Wounder

Mats Olsson

Jerker Persson

Klaus Gebauer

John Davis

Kyril Dambuleff

Petter Bennemo

Mats Ge Healthcare Bio-Sciences Ab Olsson

Jerker Ge Healthcare Bio-Sciences Ab Persson

Sven Ge Healthcare Bio-Sciences Ab Wounder

A parallel assembly () of chromatography column modules () connected in a rigid housing (), the assembly having one common assembly inlet () and one common assembly outlet (), each column module comprising a bed space () filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space () of the column module with the assembly inlet () and the assembly outlet (), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

Parallel assembly of chromatography column modules

A method for performing maintenance on a chromatography column () comprising the steps of:

Method for performing maintenance on a chromatography column

Chromatography column

A chromatography column having a longitudinal axis and comprising a column wall with a first end and a second end, a first end plate assembly removably connectable to said first end of the column wall, a second end plate assembly removably connectable to said second end of the column wall, wherein said first end plate assembly, said column wall and said second end plate assembly are arranged along the longitudinal axis of the column wherein the column wall, and/or first end plate assembly and/or second end plate assembly is/are rotatable about an axis of rotation wherein said axis of rotation is parallel to the longitudinal axis of said column and positioned outside the column.

A method for conducting maintenance on a chromatography column (), said column comprising a column tube (), a top end cell () and a bottom end cell (), where during chromatography said column tube () is secured between said top end cell () and said bottom end cell (). Said method comprises the step of rotating at least the top end cell () 180 degrees around a horizontal axis before maintenance is conducted to the top end cell ().

Chromatography column stand

A nozzle assembly () provided in a chromatography column (), said nozzle assembly comprising a nozzle tube () through which chromatography media slurry is to be provided to the column (). According to the invention said nozzle assembly () further comprises a pivot () connected in a first end () to a pivot point arm (), said pivot () can be pivoted into at least two different locked pivot positions and said pivot () being connected to the nozzle tube () such that a nozzle tip () of said nozzle tube is adjusted into at least two different locked nozzle tip positions corresponding to the at least two different locked pivot positions.

Chromatography column nozzle

In a chromatography column, at least one plastic retaining mesh is attached to a distributor plate using a fixture element comprising an elongated edge that penetrates into the plastic mesh to ensure sealing and to prevent radial movement of the plastic mesh.

Growing community of inventors

Uppsala, Sweden

Per Uselius