Nycomed Imaging As

Nycomed Salutar, Inc.

Ge Healthcare As

Nyegaard & Co A/s

Per Strande

Jo Klaveness

Pangl Rongved

Unni Nordby Wiggen

Harald Dugstad

Keith Redford

Jan Solberg

Arne Berg

Pal Rongved

Lars Stubberud

Kjell Undheim

Martha Garrity

Anne Kjersti Fahlvik

Joan F Carvalho

Shaun P Crofts

Trygve Gulbrandsen

Tore Benneche

Helge G Gundersen

Richard J Himmelsbach

Anne N&aelig;vestad

Anne Jacobsen

Michel Gacek

Balin Balinov

Joseph Arukwe

Jan Alfheim

This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ('Compound A') to iodixanol.

Alternative dimerisation reagents for synthesis of iodixanol

The invention relates to particulate contrast agents, especially contrast agents for MR imaging having a metal oxide core which is preferably superparamagnetic iron oxide. The particulate contrast agents are provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.

Ultrafine lightly coated superparamagnetic particles for MRI

The present invention provides a polyethylene glycol (PEG) ester surfactant comprising at least one polyethylene glycol moiety and at least one fatty acyl moiety characterized in that said moieties are linked by a linkage incorporating a biodegradable methylene diester unit of formula (I)

Surfactants

Polychelants as contrast enhancing agents

A method of crosslinking a crosslinkable protein or carbohydrate substrate to form a crosslinked substrate in which the crosslinking groups are biodegradable. The crosslinking groups may comprise methylene diacrylate and the substrate can be galactose.

Cross-linking agent

Hydrazide derivatives of polyamides and their medical use as chelating

Contrast agents comprising gas-containing or gas-generating

Ultrasound contrast agents comprising a microbubble-generating suspension of a microparticulate X-ray contrast agent in a liquid carrier medium.

Method of ultrasound imaging using microbubble-forming, solid X-ray

Contrast agents

The present invention relates to the process for the preparation of a biodegradable polymer comprising diester units of the formula (III)

Polymers containing diester units

Contrast agents comprising gas-containing or gas-generating polymer microparticles and/or microballoons, in which the polymer is a biodegradable polymer containing units of formula

Contrast agents comprising gas-containing or gas-generating polymer

Aggregates of x-ray microparticles for ultrasound imaging

Chemical compounds

This invention relates to ultrasound contrast agents in the form of microparticles comprising a biotolerable matrix (e.g. of a carbohydrate or an X-ray contrast agent) in association with a gas or a precursor therefor. The contrast agents are stabilized to enhance their in vivo stability and/or echogenicity by covalently modifying the structure of the matrix, e.g. to introduce crosslinking groups or to attach lipophilic groups and/or molecules. The covalent moieties may include biodegradable linkages to assist rapid subsequent elimination of the contrast agents from the system.

Gaseous microparticles as ultrasound contrast agents

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Oslo, Norway

Per Strande