Biocrine Ab

University of Miami

Biorep Technologies, Inc.

Berggren, Per-olof

Per-Olof Berggren

Alejandro Caicedo

Over Cabrera

Camillo D Ricordi

Ramon E Poo

Felipe Echeverri

Shao-Nian Yang

Barbara Leibiger

Ingo Leibiger

Veit Flockerzi

Christopher Barker

Lisa Juntti-berggren

The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.

Methods for monitoring physiological status of a body organ

Methods for treating and/or limiting development of diabetes in a subject with amyotrophic lateral sclerosis (ALS) by inhibiting IgG-mediated activation of voltage-gated calcium channels (VGCCs) in cells of the subject, by one or more of removing IgG from blood of the subject, blocking IgG from activating VGCCs in the subject; or blocking VGCCs in the subject are described, as are methods for identifying ALS patients at risk of developing diabetes.

Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis

The present invention provides novel drug discovery platforms and methods for treating diabetes.

Non-invasive in vivo imaging and methods for treating diabetes

The present invention provides novel drug discovery platforms and methods for treating type I diabetes.

Non-invasive in vivo imaging and methods for treating type I diabetes

The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic &#x3b2; cells with an amount of apolipoprotein CIII ('apoCIII') effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic &#x3b2; cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic &#x3b2; cells.

ApoIII and the treatment and diagnosis of diabetes

The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes by identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in pancreatic &#x3b2; cells.

Methods for identifying compounds for treating type 1 diabetes

A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.

Perifusion device

A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.

The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes and also provides methods for treating patients with type I diabetes and for limiting pancreatic beta cell apoptosis. The present invention also provides methods for diagnosing type I diabetes or a propensity to develop type I diabetes and methods for identifying diabetic patients to be treated with anti-apoCIII therapy.

Growing community of inventors

Solna, Sweden

Per-Olof Berggren