Biosensor Applications Sweden Ab

Pharmacia Ab

Per Månsson

Jan Smith

Bengt L Lindqvist

Tomas Malson

Teodor Aastrup

Henrik Andersson

Kjeld Jensen

Björn Sandén

Ann-Charlotte Hellgren

Shahin Loniakan

Johannes Hermans

Ann-Sofie Johansson

Björn Sanden

Jan c/o Christer Rutberg Smith

A coated metal surface on a solid support, wherein the coating consists of a protein layer firmly attached to the metal surface, and said protein layer is coupled to linker molecules that are bound to low molecular weight antigens, wherein the linker molecules are coupled to the protein layer and are bound to the antigen via functional end groups and contain between the functional end groups an aliphatic hydrocarbon of 1, 2 or 3 carbon atoms, and wherein the antigens are optionally reversibly bound to antibodies specific for the antigens, is described. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.

Coated metal surface on solid support for analyte detection by displacement

A system, device and method for detection of several individual analytes in a test solution aliquot () with an array of individually operated piezoelectric crystal microbalances are described. The system comprises a connecting station () that receives a plurality of individually specific piezoelectric crystal microbalance flow-trough cells (), each containing a piezoelectric crystal () carrying electrodes () and a coating () exposing a first member of an interaction pair specific for an individual analyte being a second member of the interaction pair. Flowing means () flows a solution () and the test solution aliquot () to and through a cell compartment of each of the cells () via the connecting station (). Power and measurement means () oscillate the piezoelectric crystal(s) (). A change in oscillating characteristics of the crystal(s) (), following interaction between the first and second members of the interaction pair, detects presence of the individual analyte(s). Further, disposable flow cells () for use in an array of individually operated piezoelectric crystal microbalances () is described.

System, device and method for detection of several individual analytes in a solution, and a disposable flow cell for use therein

An apparatus () and a method for concentrating and transferring volatile compounds contained in a sample on a detachable solid support () into a liquid for subsequent detection and/or analysis of the volatile compounds, are described. The apparatus comprises a holder () for the solid support (), means () for transporting the holder () to a heating position on a heatable plate (), an enclosed space-creating arrangement comprising the heatable plate () attached to a movable housing (), the holder (), the solid support (), a funnel () on the solid support (), and inside the funnel () a chilled member (), means inside the housing () for heating the heatable plate () to evaporate the volatile compounds which then are condensed on the chilled member (), means () for transporting the chilled member () from a cooler () to the inside of the funnel () and from there to a position () where condensed compounds are removed from the chilled member () into a liquid.

Transfer of a sample from a solid support into a liquid

In a method for producing intraocular lenses with improved optical properties, applying to the optical part of the lens a coating to protect the surface during one or more processing steps which are carried out under conditions so that the protective coating is essentially insoluble and remains adhered to the lens, and removing the coating by changing the conditions which make the coating adhere to the lens.

Method for the production of intraocular lenses

Method for extracapsular cataract extraction with or without posterior chamber intraocular lens implantation comprising chemical modification of the posterior surface of the lens capsule, at least in the optical portion of said capsule, for preventing cell attachment and growth.

Method for preventing secondary cataract

Growing community of inventors

Sollentuna, Sweden

Per Månsson