Aktiebolaget Hassle

Other

Astra Lakemedel Aktiebolag

Ab Hassle

Aktiebolaget Astra

Per Arvid Emil Carlsson

Per L Lindberg

Gunnel E Sunden

Arne E Brandstrom

Per A Carlsson

Folke L Arvidsson

Domingo Sanchez

Uli A Hacksell

John L Nilsson

John S Hjorth

Hakan V Wikstrom

Bjorn M Wallmark

Nils U Svensson

Anette M Johansson

Stig Ake Carlsson

Carl I Starke

Tomas B Alminger

Mats P Nordberg

Bengt R Andersson

David A Lee

Kjell Anders Svensson

Hakan S Larsson

Kjell F Ankner

Annie H Mattsson

Carin B Briving

Arne E Brandstroom

Bundgaard H

Gordon L Fain

Rolf A Bergman

George Sachs

Arne E Brandstram

Britt I Kallsson

Hangkan V Wikstrom

John S Hjort

The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group ##STR3## wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.

Therapeutically active fluoro substituted benzimidazoles

The novel compounds of the formula I ##STR1## and physiologically acceptable salts thereof, wherein R.sup.1 and R.sup.2, which are different is each H alkyl containing 1-4 carbon atoms or --C(O)--R.sup.5 ; wherein

Dialkoxy-pyridinyl-benzimidazole derivatives, process for their

Compounds of the formula ##STR1## wherein R.sup.3 and the NR.sup.1 R.sup.2 group are in a cis-position to each other and wherein Y is OH, R.sup.4 COO, (R.sup.5).sub.2 NCOO or R.sup.6 O either in position 5 or position 7, whereby R.sup.4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R.sup.5 is an alkyl group having 1-5 carbon atoms and R.sup.6 is an allyl or benzyl group, R.sup.1 is hydrogen or an alkyl group having 1-3 carbon atoms, R.sup.2 is an alkyl group having 1-6 carbon atoms, a phenylalkyl- or m-hydroxyphenylalkyl group with 2-4 carbon atoms in the alkyl part, or an alkenyl group with 3-6 carbon atoms other than 1-alkenyl, and R.sup.3 is an alkyl group having 1-3 carbon atoms, processes and intermediates for their preparation, pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

1-alkyl-2-aminotetralin derivatives

The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group --(CH.sub.2).sub.n ##STR3## --(CH.sub.2).sub.n COOH or --(CH.sub.2).sub.n SO.sub.3 H wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.

Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine for treating gastric acid related diseases such as gastritis, gastric ulcer, duodenal ulcer and reflux esophagitis.

Certain pyridyl[(methylthio- or methyl sulfinyl)-2

Novel compounds of the general formula I ##STR1## processes for its preparation, pharmaceutical compositions containing such compounds as the active ingredient and the use of the compounds in medicine.

Derivatives of benzimidazoles active as anti-ulcer agents

A method for the treatment of diseases related to an increased intraocular pressure in the eye comprising administration to a patient suffering therefrom an amount of a compound of the formula I ##STR1## or a pharmaceutically acceptable salt thereof.

Compounds including omeprazole in the treatment of glaucoma

The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl, or R.sup.1 is the group ##STR3## --(CH.sub.2).sub.n COOH or --(CH.sub.2).sub.n SO.sub.3 H wherein n is 1-6 and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.

Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.

Novel pharmacologically active compound pyridyl methylsulfinyl

The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimid azole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the use of the compound in medicine.

Therapeutically active cyclopropyl substituted compound

The novel compound 4-fluoro-2-[[(4-methoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing such compounds as active ingredient, and the use of the compound in medicine.

Therapeutically active fluoro-substituted compound

Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient with gastric and inhibiting effects.

Novel pharmacological compounds

5-Chloro-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as an intermediate, pharmaceutical compositions containing such compound as active ingredient, and the use of the compound in medicine.

Therapeutically active chloro substituted benzimidazole

The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the use of the compound in medicine.

Therapeutically active compound and a process for its preparation

The novel compounds of the formula I ##STR1## wherein Cl is in 5 or 6 position and whereby R is the group --CH.sub.2 OCOOR.sup.1, wherein R.sup.1 is a straight or branched alkyl containing 1-6 carbon atoms or benzyl,

Growing community of inventors

Askim, Sweden

Per L Lindberg