Symphogen A/s

Per-Johan Meijer

Mikkel Wandahl Pedersen

Allan Jensen

Klaus Koefoed

Lucilla Steinaa

Lars Soegaard Nielsen

Robert Carlsson

Charles Pyke

Lars Sogaard Nielsen

Jesper Kastrup

Soegaard Nielsen

The present invention relates to novel therapeutic antibodies directed against HER2 (ErbB2), as well as recombinant polyclonal anti-HER2 antibody compositions comprising at least two of said recombinant anti-HER2 antibodies, and use of the antibodies and antibody compositions for treatment of cancer.

Anti-HER2 antibodies and compositions

The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies showed synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody.

Recombinant anti-epidermal growth factor receptor antibody compositions

The invention relates to a procedure for linking cognate pairs of Vand Vencoding sequences from a population of cells enriched in particular surface antigen markers. The linking procedure involves a multiplex molecular amplification procedure capable of linking nucleotide sequences of interest in connection with the amplification, in particular polymerase chain reaction (multiplex PCR). The method is particularly advantageous for the generation of cognate pair libraries as well as combinatorial libraries of variable region encoding sequences from immunoglobulins. The invention also relates to methods for generation of chimeric human/non-human antibodies and expression libraries generated by such methods.

Method for cloning cognate antibodies

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Lyngby, Denmark

Per-Johan Meijer