Medivir Ab

Ciba-geigy Corporation

Per Engelhardt

Marita Hogberg

Xiao-Xiong Zhou

Nils-Gunnar Johansson

Bjorn G Lindborg

M Robert Leanna

Rolf Noreen

Christer Sahlberg

Michael Rasmussen

Katarina Beierlein

Jan-Erik Nystrom

Rolf Nor&eacute;en

Bjorn Elman

Mikael Sellen

Björn Lindborg

Christer Salhberg

Marita H&ouml;gberg

Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: 

Acyclic nucleoside derivatives

Antivirals

Compounds of formula (I): wherein R is cyano or bromo; R is halo; R is C -C alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.

Compounds of the Formula I ##STR1## where one of R.sub.1 and R.sub.2 is --C(O)CH(CH(CH.sub.3).sub.2)NH.sub.2 or --C(O)CH(CH(CH.sub.3)CH.sub.2 CH.sub.3)NH.sub.2;

A process for the production of a 5-7 membered ring cyclic sulfonium salt compound, including a 5-7 membered ring cyclic sulfonium salt compound having a non-nucleophilic anion, is described. Members of the latter group are potentially useful as initiators for cationic polymerizations. The process comprises reacting a 1.4-, 1.5-, or 1.6-diol compound or a 5-7 membered ring cyclic ether compound with a mercapto compound and a strong protonic acid yielding the cyclic sulfonium salt compound. Some compounds described are also novel compounds per se.

Process for the production of cyclic sulfonium salts

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Stockholm, Sweden

Per Engelhardt