Pierre Fabre Medicament

Pharmacia & Upjohn Aktiebolag

Per-ANGke Nygren

Mathias Uhlen

Bjorn Nilsson

Thien Ngoc Nguyen

Marianne Hansson

Stefan Stanghl

Tripartite recombinant DNA encoding fusion proteins which comprise three sequences, i.e., a signal peptide which is operable in a Gram positive bacterium, an immunogenic polypeptide linked thereto which is not normally expressed in a Gram positive bacterium, and a cell wall spanning and a membrane anchoring sequence, as well as their use in Gram positive bacteria to express the resultant fusion protein on their surface are described. The preferred cell wall spanning and anchoring polypeptides include Staphylococcus protein A and Streptococcus protein G.

Recombinant DNA coding for signal peptide, selective interacting

Bacterial receptor structures

Growing community of inventors

Skarpnack, Sweden

Per-ANGke Nygren