Global Hemostasis Institute Mgr Ab

Optovent Ab

Pentti Olavi Tengvall

Ingemar Lundstrom

Per Vilhelm Aspenberg

The method of the present invention is for coating an implant device. The implant device is coated with a protein film, such as fibrinogen. A first bisphosphonate substance, such as pamidronate, is immobilized to the protein film. A second bisphosphonate substance, such ibandronate, is adsorbed to the first bisphosphonate wherein the first bisphosphonate is different from the second bisphosphonate.

Bisphosphonate coated implant device and method therefor

An analytical method of qualitative and optionally quantitative determination of the occurrence of polymerization/coagulation in a fluid containing polymerizable/coagulable components is described. The method comprises the steps of directing incident beams of electromagnetic radiation through a transparent support on which a film of electrically conducting material is placed, to the back of the film, at angles equal to or greater than the critical angle for total reflection, and measuring changes in the reflected beams due to changes in the surface plasmon resonance angle. Repeated measurements are correlated to the occurrence and magnitude of changes with qualitative and optionally quantitative occurrence of polymerization/coagulation in the fluid. The analytical method is not volume dependent since only one (small) surface of the measuring instrument needs to be in contact with the fluid. Further, the method can also be applied to poorly transparent fluids such as blood.

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Linkoping, Sweden

Pentti Olavi Tengvall