Editas Medicine, Inc.

Penrose Odonnell

Morgan Lee Maeder

Hariharan Jayaram

Jennifer Leah Gori

Tongyao Wang

Joshua C Tycko

Patrick David Hsu

Nicholas C Huston

Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.

CRISPR/Cas-related methods and compositions for improving transplantation

Growing community of inventors

Yarmouth, ME, United States of America

Penrose Odonnell