Zymogenetics, Inc.

Cellpro Incorporated

Penny Thompson

Paul O Sheppard

Donald C Foster

Cindy A Sprecher

Julia E Novak

Stephen R Jaspers

Yasmin A Chandrasekher

Hal Blumberg

Wenfeng Xu

Katherine E Lewis

Richard M Garcia

James D Kelly

Robert R West

Billy W Minshall

Karen L Madden

Eric D Peterson

Patrick M Maloney

Fred Mill

Shelly Heimfeld

Stanley Corpuz

Maribeth A Eagan

Xu Wenfeng

Maribeth A Eagen

A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.

Method of treating rheumatoid arthritis using anti-IL-20 antibodies

Methods of treatment using anti-IL-20 antibodies

Method for treating inflammation

The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.

Methods of modulating gastrointestinal contractility

The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.

Methods of detecting or diagnosing inflammatory bowel disease using prokineticin polynucleotides

Uses of human Zven proteins and polynucleotides

Uses of human Zven antagonists

Method for treating inflammation using soluble receptors to interleukin-20

A particle separator is provided for collection and manipulation of target particles, e.g., target cells, in a closed sterile field condition. In one embodiment, closed sterile field conditions are maintained from separation through concentration and/or cryo treatment steps and/or transfusion. Preservation of closed sterile field condition are accommodated by using the same integrally coupled rigid-walled vessel for collection and concentration and transfer via integrally coupled conduits to a vessel for cryopreservation and/or transfusion. In one embodiment, a plurality of valves are responsive to a data processor for controlling the path of fluid flow through the particle separator. A plurality of sensors are provided for providing sensor signals indicative of fluid flowing through the cell separator. A peristaltic pump is responsive to the microprocessor assembly for controlling the speed and direction of fluid flow through the system. A stir plate assembly is responsive to a signal from the data processor for controllably agitating the contents of the cell separator.

Apparatus and method for particle separation in a closed field

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Snohomish, WA, United States of America

Penny Thompson