Affymetrix, Inc.

Pennina Langer-Safer

David J Lockhart

Gordon G Wong

Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

Identification of molecular sequence signatures and methods involving the same

Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide or sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

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Rehovot, Israel

Pennina Langer-Safer