Guangzhou Cellprotek Pharmaceutical Ltd.

Guangzhou Cellprotek Pharmaceutical Co., Ltd

Guangzhou Cellprotek Pharmaceuticals Ltd.

Pengxin Qiu

Guangmei Yan

Jingxia Zhang

Haiyan Hu

Jiesi Chen

Wei Yin

Wenbo Zhu

Yijun Huang

Bingzheng Lu

Tiandong Leng

Hanfei Sang

Shujia Zhou

Xiuhua You

Ling Li

Ning Tian

Halyan Hu

Use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol and analogs thereof in the preparation of a drug for the prophylaxis or treatment of an altitude sickness caused by hypobaric hypoxia is provided, so as to provide a new drug for the prophylaxis or treatment of an altitude sickness. Researches revealed that 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol treatment can effectively reduce vasogenic edema of brain tissue ofcaused by hypobaric hypoxia, reduce the increased cerebral water content, and protect from neuronal vacuolar degeneration caused by hypobaric hypoxia, therefore it can improve neurological dysfunctions caused by hypobaric hypoxia and is useful in prophylaxis or treatment of an altitude sickness.

Neuro-protective agents and uses thereof

Disclosed is the use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol in preparing neuroprotective drugs. The compound has significant protective effect against neuron injuries caused by cerebral ischemia, spinal cord ischemia or hypoxia and has no obvious toxic reaction within effective dose thereof.

Use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol in preparation of neuroprotective drugs

A 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-&#x3b2;-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-&#x3b2;-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-&#x3b2;-cyclodextrin solution, 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection. Drying the filtrate yields a solid for injection.

5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol injection and preparation method therefor

A 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol injection and its preparation are disclosed. The injection uses hydroxypropyl-&#x3b2;-cyclodextrin as a solubilizing agent and the active ingredient is present at a weight ratio of 1-20:40-500 to the hydroxypropyl-&#x3b2;-cyclodextrin. The injection may also comprise, by weight, 1-100 parts of at least one isotonic adjusting agent, 0-200 parts of at least one freeze drying filler, and 0-2000 parts of at least one solvent. The preparation method comprises dissolving hydroxypropyl-&#x3b2;-cyclodextrin solution, 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol and at least one additional soluble excipient in water for injection in sequence to obtain a raw injection solution, and subjecting the raw injection solution to decolorization, depyrogenation, filtration and sterilization to obtain the injection, Drying the filtrate yields a solid for injection.

5&#x3b1;-androstane (alkyl)-3&#x3b2;, 5, 6&#x3b2;-triol injection and preparation method therefor

Disclosed is the use of 5&#x3b1;-androstane(alkyl)-3&#x3b2;,5,6&#x3b2;-triol in preparing neuroprotective drugs. The compound has significant protective effect against neuron injuries caused by cerebral ischemia, spinal cord ischemia or hypoxia and has no obvious toxic reaction within effective dose thereof.

Use of 5&#x3b1;-androstane (alkyl)-3&#x3b2;,5,6&#x3b2;-triol in preparation of neuroprotective drugs

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Guangzhou, China

Pengxin Qiu