Hangzhou Normal University

Hangzhou Transfar Fine Chemical Co., Ltd.

Hangzhou Loop Biotech Co., Ltd

University of Shaoxing

Zhejiang Transfar Functional New Material Co., Ltd.

Great Forest Biomedical Ltd.

Zhejiang Benli Technology Co., Ltd.

Hangzhou Zheda Jingyi Electromechanical Technology Corporation Limited

Zhejiang Zoch Technology Co. Ltd.

Pengfei Zhang

Weiming Xu

Wanmei Li

Chao Shen

Xiaoling Li

Jun Xu

Xiaojun Wang

Lianzhi Tao

Hongyun Shen

Dongxiang Feng

Kejie Chai

Bajin Chen

Shengpeng Wang

Runpu Shen

Wei Liu

Chunlei Wu

Cheng Wang

Yan Zhang

Xiang Zhao

Xiaobo Yang

Binqi Rao

Jinxing Song

Yuzhi Guo

Yunpeng Hou

Shicheng Zhang

Tong Wu

Kui Du

Kaiqiang Yan

Jinsong Wang

Keyun Wang

Ke Shi

Huilin Zheng

Chunyu Dai

Haining Gu

Haifeng Wu

Zhifeng Tang

Fuzai Lv

Weixu Liu

Wei Huang

Jiabin Shen

Bencheng Yu

Youju Huang

For assembling a heat pump, an apparatus includes a loading part located in an initial section of the fully automatic intelligent production line of an integrated thermal management module. The apparatus includes a first assembling part, located downstream of the loading part, that assembles a refrigerant side components of the heat pump. The apparatus includes a first testing part, located downstream of the first assembly part, that tests the refrigerant side components. The apparatus includes a second assembling part, located downstream of the loading part, that assembles the cooling water side components of the heat pump. The apparatus includes a second testing part, located downstream of the second assembling part, that tests the cooling water side components. The apparatus includes a finished product part, located downstream of the second testing part, that outputs a finished product.

Apparatus for assembling a heat pump

A method for monitoring a service state of a switch rail based on feature fusion includes: mounting an ultrasonic guided wave monitoring apparatus on the switch rail to perform online defect identification and simulation of the switch rail, and establishing a baseline signal library, where the ultrasonic guided wave monitoring apparatus generates a guided wave signal propagating along the switch rail and receives an echo signal of the guided wave signal; performing feature extraction; extracting a healthy feature vector, and nondimensionalizing; selecting a defect-sensitive feature, and acquiring, by a BPSO algorithm, a best feature subset; training an LS-SVM through the best feature subset by a cross-validation method to acquire an automatic online defect identification model of the switch rail based on the LS-SVM; and monitoring the switch rail by the automatic online defect identification model of the switch rail based on the LS-SVM.

Method for monitoring service state of switch rail based on feature fusion

Disclosed are (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-bromo-2,2-difluoroacetate, a waterborne polyurethane, and preparation methods thereof. The (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-bromo-2,2-difluoroacetate could be used as a modified monomer for preparing a waterborne polyurethane, and substituents at a C2 position of the (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-bromo-2,2-difluoroacetate are two fluorine atoms and one bromine atom. When it is used for preparing the waterborne polyurethane, fluorine and bromine groups are introduced into the structure of the waterborne polyurethane, and the resultant waterborne polyurethane exhibits good moisture resistance and flame retardance.

2,2-dimethyl-1,3-dioxolan-4-yl-methyl 2-bromo-2,2-difluoroacetate, waterborne polyurethane, and preparation methods thereof

The present invention relates to the field of catalysts, and provides a porous layered transition metal dichalcogenide (TMD) and a preparation method and use thereof. The preparation method includes the following steps: (1) mixing silica microspheres, a transition metal salt and an elemental chalcogen, and pressing to obtain a tablet, the silica microspheres having a same or different particle diameters; and (2) sintering the tablet under hydrogen, and removing the silica microspheres to obtain the porous layered TMD. The porous layered TMD prepared by the method of the present invention has a high lattice edge exposure, which provides more active sites and higher catalytic activity, so the porous layered TMD can effectively catalyze the oxidation of alcohols to aldehydes or sulfides to sulfoxides under visible light irradiation.

Porous layered transition metal dichalcogenide and preparation method and use thereof

The present invention relates to the technical field of chemical synthesis of pharmaceutical chemicals, and provides a 6H-imidazo[4,5,1-ij]quinolone, a synthesis method and use thereof. 6H-imidazo[4,5,1-ij]quinolone derivatives provided by the present invention are a novel group of active quinolone derivatives, which have tumor cell inhibition activity and exhibit ICvalues equivalent to anti-lung cancer drug osimertinib; these quinolone derivatives have a broad application prospect in the preparation of antitumor drugs. The 6H-imidazo[4,5,1-ij]quinolone provided by the present invention is of high research and application value and has potential application prospects in fields of pharmaceutical chemicals, materials, dyes, etc. The present invention uses thioquinolinamide as a raw material to synthesize 6H-imidazo[4,5,1-ij]quinolones, featuring simple operation, excellent selectivity, high yield, mild reaction conditions, and easy product separation.

6H-imidazo[4,5,1-ij]quinolone, synthesis method and use thereof

A method for preparing alkynyl 2-halo-2,2-difluoroacetate is disclosed. The method comprises: subjecting a 2-halo-2,2-difluoro acetic acid, an alkynol, and a catalyst to an esterification reaction in a solvent, to obtain alkynyl 2-halo-2,2-difluoroacetate, wherein the catalyst includes one or more of sulfuric acid, phosphoric acid and p-toluenesulfonic acid.

Method for preparing alkynyl 2-halo-2,2-difluoroacetate

The disclosure provides processes for preparing 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile and for preparing sulindac, relating to the field of medicine. The former comprises mixing 6-fluoro-2-methyl-1-indanone, cyanoacetic acid, a first organic solvent and an acetic acid-based catalyst to proceed with a first condensation reaction to give a first condensation reaction solution, which contains 5-fluoro-2-methyl-3-indanacetonitrile; and mixing the first condensation reaction solution, per se, with a base, a second organic solvent and 4-(methylthio)benzaldehyde to proceed with a second condensation reaction to give 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile. The process is a one-pot process without separation of 5-fluoro-2-methyl-3-indanacetonitrile from the solvent, shortening the synthetic route, simplifying the preparation process and improving the 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile yield.

Processes for preparing 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile and for preparing sulindac

A novel quinolone derivative and methods of its preparation are described in which the novel derivative comprises a diphenyl ether substituent on the nitrogen atom at the 1-position of the main quinolone ring. The novel derivative is shown to have antibacterial and anti-tumor cell activity.

Quinolone derivatives, preparation methods and application thereof

The present invention provides a method for preparing levobunolol hydrochloride. In the present invention S-1-tert-butyl-epoxy methylamine is subjected to a substitution reaction with 5-hydroxy-1-tetralone, and acidified to obtain the target product levobunolol hydrochloride. The method provided by the present invention greatly improves the regioselectivity of the reaction, avoids the occurrence of side reactions, and effectively improves the yield and optical purity of levobunolol hydrochloride, with the yield being 87.3%, and the ee value being over 99%.

Method for preparing levobunolol hydrochloride

The present invention provides a method for preparing a resveratrol compound, and belongs to the technical field of organic synthesis. In the present invention, first alkoxy-substituted benzyl halide, alkoxy-substituted benzaldehyde and a metal catalyst are subjected to oxidative addition and reduction elimination reactions to obtain alkoxy-substituted diphenylethanone; and then the alkoxy-substituted diphenylethanone and a metal catalyst are subjected to reduction, trans elimination and selective debenzylation reactions under a hydrogen atmosphere to obtain the resveratrol compound. In the preparation method of the present invention, the hydrogenation reduction, trans elimination and selective debenzylation reactions can be achieved just by a one-pot process, where the reaction directly obtains a trans olefin, thereby avoiding the formation of a isomer; and also the reaction selectively catalyzes debenzylation to eliminate Lewis acids from the source, and has the advantage of a high yield. Therefore, this process is a green and environmentally friendly process. The experimental results show that, the products obtained by the preparation method as provided by the present invention are all trans olefins, with the purity being up to more than 99.5%, and each yield being greater than 80%.

Method for preparing resveratrol compound

The present invention discloses a core-shell structure supported tungsten composite catalyst and a preparation method and use thereof. Most of the existing synthesis methods of the main ring of quinolone drugs have the defects of many synthesis steps, cumbersome operation, large amount of three wastes, higher costs and the like. The present invention prepares a magnetic separable core-shell supported tungsten composite catalyst, WO/SiO/FeO, by preparing FeOcolloid and SiO/FeOcomposite nano-particles. This magnetic separable core-shell supported tungsten composite catalyst, WO/SiO/FeO, is used to catalyze and synthesize quinolone compounds. The present invention provides an efficient preparation method of quinolone compounds using a catalyst which can be recovered by magnetic separation and recycled. The catalyst prepared by the present invention can be reused in the preparation of quinolone compounds and still retains the original activity without deactivation, which not only greatly improves the production efficiency, but also reduces the environmental pollution.

Core-shell structure supported tungsten composite catalyst and preparation method and use thereof

The invention discloses a series of resveratrol-derivative fluorescently labeled molecules and a synthesis method thereof. The fluorescently labeled molecules has a molecular formula as shown in formula (I). The synthesis method includes the steps of adding a certain amount of resveratrol derivative and solvent in a reaction vessel, adding a fluorescent marker as shown in formula (III) and a certain amount of alkali, reacting at 20&#xb0; C.-60&#xb0; C. for 2-10 hours, and after the reaction is completed, spin-drying the reaction solvent and performing post-processing to obtain the products.

Series of resveratrol-derivative fluorescently labeled molecules and synthesis method thereof

The present invention describes a novel synthetic method for preparing the key intermediate 2,6,10-trimethyl-1,1-dialkoxy-3,5,9-undecatriene of lycopene. An existing synthetic method have some disadvantages that it is very difficult to gain the raw material dialkyl 4-methyl-5,5-diakoxy-1-pentene-1-phosphonate (10) because no effective synthetic method can be adopted, and furthermore the obtained target compound is composed of several cis/trans isomers. This invention relates to a process comprising a condensation step wherein a starting C10-phosphonate is changed to its carbanion completely at a temperature of &#x2212;40&#x2dc;30 under an atmosphere of a non-reactive gas in an organic solvent catalyzed by base, and then C4-dialkyl is added to undergo Wittig-Horner condensation. This invention affords all trans C14-acetal and this method is characterized with the advantages of simple procedure, easy access to raw material and low cost, which makes it has the value of industrial application.

Method of preparing 2,6,10-Trimethyl-1,1-dialkoxy-3,5,9-undecatriene used as an intermediate of lycopene

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Hangzhou, China

Pengfei Zhang