Eureka Therapeutics, Inc.

Pengbo Zhang

Hong Liu

Yiyang Xu

Lianxing Liu

Hongruo Yun

Lucas Horan

Javier Morales

Binnaz K Staley

Shan Li

Zhiyuan Yang

Jingyi Xiang

Timothy M Acker

Guangyan Xiong

Yoko Nakano

Yixiang Xu

Shaohua Xu

Xiaomei Ge

Jun Cui

The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.

Constructs targeting prostate-specific membrane antigen (PSMA) and uses thereof

The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.

Constructs trageting CD22 and uses thereof

The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

Constructs specifically recognizing glypican 3 and uses thereof

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Fremont, CA, United States of America

Pengbo Zhang