University of Michigan

Other

Peng Zou

Duxin Sun

Shaomeng Wang

Donna McEachern

Yujun Zhao

Wei Sun

Sanjeev Kumar

Shanghai Yu

Joseph Mitchell West

Travis H Jones

Vishwanath V Subramaniam

Jennifer McFerran Brock

Emily Sequin

Differences of electromagnetic (EM) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying EM field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. In some aspects, a change in phase shift between the voltage in a receiver coil and the voltage in a driver coil provide a direct and immediate indication of differences in EM properties of specimens.

Electromagnetic system and method

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

Spiro-oxindole MDM2 antagonists

Growing community of inventors

Ann Arbor, MI, United States of America

Peng Zou