Les Laboratoires Servier

Cadence Design Systems, Inc.

Les Laboratories Servier

Guangdong Raynovent Biotech Co., Ltd.

Peng Zhang

Zhedong Yuan

Hanbin Shan

Xiong Yu

Hongjuan Pan

Xueyan Zhu

Xing Liu

Li Zhang

Yu Huang

Xiaoxin Chen

Chaofeng Long

Zhuowei Liu

Hubo Wang

Xingdong Cheng

Xudong Jiang

Xufeng Cao

Shuhui Chen

Nan Zhuang

Yuhua Yang

Linyun Wu

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNF&#x3b1; inhibitors, in particular, the compounds as shown in formula (I), or tautomers or pharmaceutically acceptable salts thereof. 

Hydroxyl purine compounds and use thereof

An apparatus and method are provided for removing redundant logic in a logic design of an integrated circuit (IC) design. The apparatus and method optimizes the integrated circuit by selecting stuck-at constant registers in the logic design, propagating a constant output value of the stuck-at constant registers across output nets of the stuck-at constant registers, identifying redundant logic in the logic design based on the propagation of the constant input value across the output net of the stuck-at constant register, and removing the redundant logic in the logic design.

Method and system for reducing redundant logic in an integrated circuit

The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.

Agomelatine hydrobromide hydrate and preparation thereof

The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.

Agomelatine hydrochloride hydrate and preparation thereof

The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble, more stable, and of higher purity than agomelatine itself, making it more suitable to be used in pharmaceutical preparation. Using this method, product of high purity can be obtained through a simple process, without having to incur further complicated steps.

Agomelatine hydrohalide complex and preparation method thereof

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Pudong New Area, China

Peng Zhang