Decode Genetics Ehf

Decode Genectics Ehf.

Peng Yu

Mark E Gurney

Jasbir Singh

Vincent Premaratna Sandanayaka

Lei Zhao

Louis J Bedell

Rama K Mishra

David E Zembower

Nian E Zhou

Bjorn Mamat

Wayne Edward Zeller

Alexandre Mikhaylovich Polozov

The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula &#x3a8;:  An example is 

Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation

Two chemical genera of pyrazolylphenyl and pyrrolylphenyl derivatives are disclosed. They have the general formula: In these compounds ring (a) is a pyrazole or pyrrole; Q is selected from the group consisting of a direct bond, O, S, SO, SO, NR, CH, CF, and C(O); HET is a 4-7-membered saturated nitrogenous heterocycle; and taken together ZW is H or Z is (CH)in which one or two (CH) may optionally be replaced by &#x2014;O&#x2014;, &#x2014;NR&#x2014;, &#x2014;SO&#x2014;, &#x2014;S(O)&#x2014;, &#x2014;C(&#x2550;O)&#x2014; or &#x2014;C&#x2550;O(NH)&#x2014;; and W is hydrogen, acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, &#x2014;COOalkyl, &#x2014;CHO, heterocyclyl, substituted aryl or substituted heterocyclyl. The compounds are inhibitors of LTA4H (leukotriene A4 hydrolase). They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation

Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is: 

Carboxylic acid peri-substituted bicyclics for occlusive artery disease

Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is: 

Sulfonamide peri-substituted bicyclics for occlusive artery disease

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Lisle, IL, United States of America

Peng Yu