Evolved by Nature, Inc.

Peng Xu

Gregory H Altman

Carlos J Bosques

Rebecca L Lacouture

Erlei Jin

Patrick Yacono

Patrik Johansson

Hyaluronic acid and silk fibroin or silk fibroin fragments tissue fillers and methods of making and using the same are provided herein. In some embodiments, the disclosure relates to a biocompatible tissue filler comprising silk fibroin or silk fibroin fragments, hyaluronic acid (HA), and polyethylene glycol (PEG) and/or polypropylene glycol (PPG), wherein a portion of the HA is modified or crosslinked by one or more linker moieties comprising one or more of polyethylene glycol (PEG), polypropylene glycol (PPG), and a secondary alcohol, wherein the linker moieties are attached to the HA at one end of the linker.

Silk-hyaluronic acid tissue fillers and methods of making and using the same

Hyaluronic acid and silk protein fragments based tissue fillers and methods of using the same are provided herein.

Silk-hyaluronic acid based tissue fillers and methods of using the same

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Lexington, MA, United States of America

Peng Xu