Centre National De La Recherche Scientifique

Paris Sciences Et Lettres-quartier Latin

Ecole Superieure De Physique Et Chimie Industrielles De La Ville De Paris

Kingfa Sci.&tech.co., Ltd.

Peng Xiao

Mathias Fink

Xianbo Huang

Albert Claude Boccara

Nanbiao Ye

Viacheslav Mazlin

Jinfeng Fu

Wangping Qin

According to one aspect, the invention relates to a system () for in vivo, full-field interference microscopy imaging of a scattering three-dimensional sample. It comprises a full-field OCT imaging system () for providing en face images of the sample, wherein said full-field OCT system comprises an interference device () with an object arm () intended to receive the sample and a reference arm () comprising an optical lens () and a first reflection surface (), and an acquisition device () configured to acquire a temporal succession of two-dimensional interferometric signals (I, I) resulting from interferences produced at each point of an imaging field; an OCT imaging system () for providing at the same times of acquisition of said two-dimensional interferometric signals, cross-sectional images of both the sample and a first reflection surface () of said full-field OCT imaging system (); a processing unit () configured to determine a plurality of en face images (X-Y) of a plurality of slices of the sample, each en face image being determined from at least two two-dimensional interferometric signals (I, I) having a given phase shift; determine from the cross-sectional images provided by the OCT imaging system () at the times of acquisition of each of said two two-dimensional interferometric signals (I, I) a depth (z) for each en face image (X-Y) of said plurality of slices; determine a 3D image of the sample from said plurality of en face images of said plurality of slices of the sample and depths.

Methods and systems for in vivo full-field interference microscopy imaging

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Guangzhou, China

Peng Xiao