Polyanalytik Inc.

Peng Xiang

Amer Ebied

Solmaz Karamdoust

Eric D Landry

In general, this invention discloses methods for extracting and analyzing coatings from implanted and excised animal tissue medical devices; wherein the coating comprises at least one biodegradable polymer and at least one or more therapeutic ingredients. The present invention describes optimal conditions for extraction and isolation of biodegradable polymers and therapeutics in medical devices or complex pharmaceutical agent formulations prior and after implanting or injecting into animal tissues. Particularly this work relates to accurate isolation and quantification of ppm amounts of polymer and/or therapeutics without biological interferences. The use of GPC/SEC systems equipped with light scattering detectors enables 'absolute' or “true” molecular weight determination. All of these improvements allow for accurate determination of the degradation profile of the polymer/therapeutic component independent of polymer standards used in conventional GPC/SEC.

Growing community of inventors

London, Canada

Peng Xiang