Zhejiang Huahai Pharmaceutical Co., Ltd.

Hangzhou Hikvision Digital Technology Co., Ltd.

Zhejiang Huahai Zhicheng Pharmaceutical Co., Ltd

Alibaba Group Holding Limited

Zhejiang Huahai Pharmaceuticals Co., Ltd.

Zheijiang Huahai Pharmaceutical Co., Ltd.

Peng Wang

Wenling Zhang

Pan Guo

Musong Liu

Zhiwen Zeng

Xini Zhang

Yifeng Wang

Shiliang Pu

Jian Chen

Chao Wang

Bin Guo

Ye Ren

Wencong Zhang

Xi Chen

Wenquan Zhu

Jinsheng Lin

Min Li

Weiwei Cai

Peng Dong

Xiaochen Quan

Renguang Feng

Yuanxun Zhu

Tingqun Ye

Changming Yang

Xing Zheng

Xiaoren Zhu

Xiaohui Zhou

Zhongyao Wang

Yongbi Chen

Lingjie Chen

Zengle Zhou

Jianfeng Peng

Zhiqiang Zhou

Jiale Fang

Xiaoxiao Xu

The present invention relates to a method for preparing pregabalin by a biological enzyme method. In particular, the method comprises producing pregabalin B and an R-configuration compound C by using a compound A as a raw material under the action of a biological enzyme; performing configuration inversion of the separated and recovered R-configuration compound C under the action of an isomerase to produce an S-configuration compound D; and producing pregabalin B from the compound D under the action of a biological enzyme.

Method for preparing pregabalin

A method for synthesizing valsartan, comprising the steps of: synthesizing a valsartan methyl ester intermediate to obtain a reaction mixture of the valsartan methyl ester intermediate; diluting the reaction mixture by salt water or water, and then using a first extraction solvent to extract the valsartan methyl ester intermediate; adding alkali to an organic layer containing the valsartan methyl ester intermediate for hydrolyzing, removing the organic layer, regulating pH of a water layer to be acidic by using acid, using the first extraction solvent to extract, concentrating a part of solvent, or distilling the solvent to dryness, and then adding a new solvent; finally, crystallizing, filtering, and drying to obtain the valsartan.

Method for synthesizing valsartan

A method for preparing pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting compound (I) 3-isobutylglutaric acid, as a raw material, with a nitrogen-containing agent to produce compound (II) 3-isobutylglutarimide; and performing stereoselective ring-opening of compound (II) under the action of a biological enzyme to produce compound (III) (R)-3-(carbamoylmethyl)-5-methylhexanoic acid: 

Method for preparing pregabalin intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid

The present application relates to the field of security and protection, and provides a pan-tilt control method, device and system. The method comprises: detecting whether there is a signal source within a monitored region of a pan-tilt camera, the pan-tilt camera comprising a pan-tilt and a camera attached to the pan-tilt; judging, when there is a signal source within the monitored region, whether signals emitted from the signal source are position adjusting signals for indicating a position adjustment on the pan-tilt; and adjusting a position of the pan-tilt according to a position of the signal source when the signals emitted from the signal source are position adjusting signals. In the present application, the trigger delay of the control operation on the pan-tilt camera is reduced.

Pan-tilt control method, device and system

Embodiments of the present application provide a method and apparatus for updating an online self-learning event detection model. The method includes: presenting, when at least one target alerting event generated by the current event detection model is detected, to a user the at least one target alerting event, so that the user provides an event result for each target alerting event based on the at least one presented target alerting event; obtaining the event result for each target alerting event provided by the user based on the at least one presented target alerting event; determining whether a target alerting event for which an event result has been provided by the user satisfies a predetermined update condition, and if so, training and obtaining a target event detection model based on at least one target alerting event for which an event result has been provided by the user and corresponding event result, and predetermined training samples; and replacing the current event detection model with the target event detection model. By means of the method and apparatus according to the present application, the current event detection model may be continually updated, and thus improving the accuracy of the online learning.

Method and device for updating online self-learning event detection model

Embodiments of the disclosure provide methods and apparatuses for identifying fake traffic. The method can includes: collecting access traffic data of network traffic; generating feature data of the access traffic data; and sending the feature data to a server for identifying fake traffic in accordance with the feature data.

Method and apparatus for identifying fake traffic

Provided is a method for preparing a pregabalin intermediate 3-isobutylglutaric acid monoamide. The method comprises: 1) adding 3-isobutylglutaric acid and urea into a first organic solvent; 2) keeping warm and refluxing when heated to 100-140&#xb0; C.; 3) adding water when cooled to 70-90&#xb0; C.; 4) adding an ion membrane alkaline when cooled to 40-60&#xb0; C., adjusting the pH to 11.0-14.0, then keeping warm at 40-60&#xb0; C.; 5) when finished keeping warm, removing an organic layer; 6) adding an acid into the water layer to adjust the pH to 1.0-3.0; 7) extracting the solution acquired in step 6) by using a second organic solvent of a total volume of V, vacuum distilling 0.5-0.6 V of the organic solvent from an organic layer acquired by extraction; and 8) cooling to 0-15&#xb0; C. and crystallizing to acquire 3-isobutylglutaric acid monoamide.

Method for preparing pregabalin intermediate 3-isobutylglutaric acid monoamide

Provided is a purifying method for dabigatran etexilate free base, comprising subjecting a dabigatran etexilate free base crude product to water slurrying to obtain a crude product B; then conducting recrystallization on the crude product B with acetone and water to obtain a crude product C; and subsequently, purifying the crude product C with a mixed solvent of tetrahydrofuran and ethyl acetate, filtering and drying to obtain a dabigatran etexilate free base finished product. The purifying method of the present invention can effectively remove various impurities and is suitable for workshop production. Salts and water-soluble organic impurities are removed by purified water slurrying, impurities with a high polarity are removed by purifying with an acetone-water solution, and impurities with a low polarity are removed by purifying with a mixed solvent of tetrahydrofuran and ethyl acetate.

Preparation process for high-purity dabigatran etexilate

The disclosure discloses a method, device and system for target tracking. Wherein, the method for target tracking includes that: Global Positioning System (GPS) information of a target object monitored by tracking equipment is acquired (S); Pan/Tilt/Zoom (PTZ) coordinate information corresponding to the GPS information of the target object is obtained according to a pre-stored conversion relationship between GPS information and PTZ coordinate information (S); and the tracking equipment is regulated to control the tracking equipment to monitor the target object according to the PTZ coordinate information of the target object (S). The problem of inaccuracy of a monitoring result of a method for monitoring a tracking target in the conventional art is solved.

Method, device and system for target tracking

The present invention provides a method for preparing a pregabalin intermediate 3-carbamoymethyl-5-methylhexanoic acid without solvent. The method comprises the following steps: a) cooling an ammonia water system to a certain temperature; b) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; c) after completing the reaction, adding an acid to the system to adjust pH; d) after adjusting pH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and e) adding a solvent to the dried substance, slurrying, and suction filtering and drying to obtain the final product. The method provided in the present invention for preparing 3-carbamoymethyl-5-methylhexanoic acid is high-yield, green, environmentally-friendly, simple and convenient, and of less pollution.

Method for preparing pregabalin intermediate 3-carbamoymethyl-5-methylhexanoic acid without solvent

The present invention relates to a method of refining valsartan comprising more than or equal to 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than or equal to 10% D-isomers to dissolve it, then adding a certain amount of inorganic base, separating solids out after salification, distilling a filtrate after filtration, and distilling the filtrate to remove the organic solvent; adjusting the pH of the filtrate with an acid, extracting with an organic solvent, concentrating most of the organic solvent, cooling to crystallize, and obtaining the product. The method enables isomers of the product to be below 0.5%, and produce a yield of more than or equal to 40%, being suitable for industrial production.

Method of refining valsartan comprising more than or equal to 10% D-isomers

A method for preparing rocuronium is disclosed. 2&#x3b2;-(4-Morpholinyl)-16&#x3b2;-(1-pyrrolidinyl)-5&#x3b1;-androstan-3&#x3b1;-ol-17&#x3b2;-acetate is used as a starting material and is directly reacted with 3-bromopropene at ambient temperature to produce rocuronium.

Preparation method of rocuronium

Provided is a method for purifying rocuronium bromide, which comprises: formulating crude rocuronium bromide to be purified into an aqueous solution, distilling off excess residue solvents at reduced pressure, absorbing by adding active carbon or silica gel, then filtrating, quick freezing the filtrate into ice, and then lyophilizing to obtain rocuronium bromide.

Method for purifying rocuronium bromide

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Taizhou, China

Peng Wang