Eli Lilly and Company

Medtronic, Inc.

Restoragen, Inc.

Nps Pharmaceuticals, Inc.

Peng Luan

Yuannan Xia

Ying Tang

Derrick Ryan Witcher

Donmienne Doen Mun Leung

Fred W Wagner

Daniel J Strydom

Jin Seog Seo

James Arthur Williams

Barbara Anne Swanson

Barton Holmquist

Scott Harley

Mary J Bossard

Joseph Vincent Manetta

Edwin H Merrifield

Donmienne Doen Leung

Pia Pauliina Yachi

Yuping Anthony Cai

Luhong He

Dennis Patrick Gately

The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.

Methods of DNA constructs for high yield production of polypeptides

Methods and DNA constructs for high yield production of polypeptides

Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.

Anti-hepcidin antibodies and uses thereof

Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.

Anti-ferroportin 1 monoclonal antibodies and uses thereof

Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.

Anti-hepcidin-25 selective antibodies and uses thereof

The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.

Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides

The invention provides methods and nucleic acid constructs to express clostripain. The source of the coding region for recombinantly expressed clostripain is

Methods and constructs for high yield expression of clostripain

Method for universal enzymatic production of bioactive peptides

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Fishers, IN, United States of America

Peng Luan