Emory University

Chinese Academy of Sciences

Duke University

The Rockfeller University

Peng Jin

Jack D Keene

Robert Darnell

Scott A Tenenbaum

Stephen T Warren

Victoria Brown-Kennerly

Stephanie Ceman

Jennifer C Darnell

Qinmiao Sun

Dahua Chen

Weiqi Tan

Abrar Qurashi

Provided is a protein coded by a gene related to cell totipotency and a transcriptional activation domain of a mammalian YAP protein or a fusion protein of a segment with a transcriptional control activity, a coding nucleotide sequence, an expression vector and a composition thereof, as well as a method for inducing the pluripotent stem cells by using the fusion protein.

Fusion protein for inducing pluripotent stem cells and application method thereof

Compositions and methods of treatment or prophylaxis of fragile-X associated disorders are provided, as well as methods of screening compounds and kits to screen a library of compounds.

Compositions and methods for treating fragile X premutation RVGG repeats-mediated toxicity

Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal antibody to FMRP and a consensus sequence for the RNA binding region has been identified. Arrays for identifying compounds, proteins, nucleotides, and the like that modulate the RNA targets or associated genes are provided. Additionally, methods for modulating RNA targets are provided.

Method and identification of downstream mRNA ligands to FMRP and their role in fragile X syndrome and associated disorders

Growing community of inventors

Atlanta, GA, United States of America

Peng Jin