Auson Pharmaceuticals Inc.

Peng Hou

Enxian Lu

Longlong Feng

Long Wang

The present invention provides a pharmaceutical composition of diltiazem hydrochloride. The pharmaceutical composition is preferably a gel and consists of diltiazem hydrochloride and excipients including propylene glycol, benzoic acid, and a gel matrix, which is one of or a mixture of povidone and hydroxypropyl cellulose. Based on percentage by weight, the diltiazem hydrochloride accounts for 1%-5%, the benzoic acid accounts for 0.1%-5.0%, the gel matrix accounts for 5%-10%, and the balance is propylene glycol, with pH maintained at 3.0-4.5. A preparation method is provided accordingly, with simple and readily available raw materials and stable quality.

Pharmaceutical composition of diltiazem hydrochloride, preparation method therefor, and application thereof

Disclosed herein is a fast-dispersing suspending composition which promotes the formation of a suspension for pharmaceutical, food and veterinary products. The composition includes a suspending agent, a diluent, and a glidant, wherein the amounts of these agents are selected to enable the dispersion of the composition and the formation of the suspension. Also disclosed are a method of forming a suspension of a solid dosage form and a method of administering the resulting suspension to a subject.

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Shanghai, China

Peng Hou